Cargando…

Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis

Rationale: Hyperlipidemia is a major risk factor of atherosclerosis and cardiovascular diseases (CVD). As a standard-of-care approach for hyperlipidemia, statins only reduce the risk of coronary artery disease by 20-40%, underscoring the importance of identifying molecular pathways for the design of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Tianpeng, Shi, Hongtao, Liu, Ningning, Tian, Jing, Zhao, Xiaoling, Steer, Clifford J., Han, Qinghua, Song, Guisheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086368/ https://www.ncbi.nlm.nih.gov/pubmed/32226531 http://dx.doi.org/10.7150/thno.39578

Ejemplares similares

MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis
por: Liu, Ningning, et al.
Publicado: (2022)

Cerebrovascular Changes and Neurodegeneration Related to Hyperlipidemia: Characteristics of the Human ApoB-100 Transgenic Mice
por: Tóth, Melinda E., et al.
Publicado: (2020)

Investigation of human apoB48 metabolism using a new, integrated non‐steady‐state model of apoB48 and apoB100 kinetics
por: Björnson, E., et al.
Publicado: (2019)

Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation
por: Lin, Huige, et al.
Publicado: (2022)

LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA‐378 Transcription and Inhibition of Ppargc1β Expression
por: Zhang, Tianpeng, et al.
Publicado: (2019)

Uptake of (68)gallium in atherosclerotic plaques in LDLR(-/-)ApoB(100/100 )mice
por: Silvola, Johanna MU, et al.
Publicado: (2011)

Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE(-/-) mice
por: Dunér, Pontus, et al.
Publicado: (2021)

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
por: Mobin, Mehrpouya B., et al.
Publicado: (2016)

Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100
por: Tse, Kevin, et al.
Publicado: (2013)

Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis
por: Dimayuga, Paul C., et al.
Publicado: (2017)

Biphasic Production of Anti-ApoB100 Autoantibodies in Obese Humans and Mice
por: Choe, Moon Kyung, et al.
Publicado: (2021)

Immunization using ApoB-100 peptide–linked nanoparticles reduces atherosclerosis
por: Chyu, Kuang-Yuh, et al.
Publicado: (2022)

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr(−/−)ApoB(100/100) Mice
por: Koponen, Markus, et al.
Publicado: (2023)

Autoantibodies Against ApoB-100 as a New Marker of Coronary Vulnerable Plaque
por: Egusa, Genshi
Publicado: (2021)

CD8(+) T Cells Mediate the Athero-Protective Effect of Immunization with an ApoB-100 Peptide
por: Chyu, Kuang-Yuh, et al.
Publicado: (2012)

Increased Tau Phosphorylation and Impaired Presynaptic Function in Hypertriglyceridemic ApoB-100 Transgenic Mice
por: Lénárt, Nikolett, et al.
Publicado: (2012)

Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR(−/−) Mouse Strain
por: Lantos, Ildikó, et al.
Publicado: (2018)

Regulation of plasma LDL: the apoB paradigm
por: Sniderman, Allan D., et al.
Publicado: (2009)

ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage
por: Ramírez, Carlos, et al.
Publicado: (2011)

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets
por: Suzuki, Michitaka, et al.
Publicado: (2012)

Subjects with Molecularly Defined Familial Hypercholesterolemia or Familial Defective apoB-100 Are Not Being Adequately Treated
por: Leren, Trond P., et al.
Publicado: (2011)

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis
por: Gong, Yi, et al.
Publicado: (2013)

Glycosyltransferase GLT8D2 Positively Regulates ApoB100 Protein Expression in Hepatocytes
por: Wei, Hong-Shan, et al.
Publicado: (2013)

T-Cells Specific for a Self-Peptide of ApoB-100 Exacerbate Aortic Atheroma in Murine Atherosclerosis
por: Shaw, Michael K., et al.
Publicado: (2017)

Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population
por: Gu, Q-L., et al.
Publicado: (2017)

Mouse, but Not Human, ApoB-100 Lipoprotein Cholesterol Is a Potent Innate Inhibitor of Streptococcus pneumoniae Pneumolysin
por: Wade, Kristin R., et al.
Publicado: (2014)

In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR(–/–)ApoB(100/100) mice
por: Blanco, Fabiana, et al.
Publicado: (2018)

Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion
por: Lee, Hwa Young, et al.
Publicado: (2016)

Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio—Experience from the Swedish AMORIS cohort: A cohort study
por: Walldius, Göran, et al.
Publicado: (2021)

Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice
por: Honjo, Tomoyuki, et al.
Publicado: (2015)

ApoB48 as an Efficient Regulator of Intestinal Lipid Transport
por: Lo, Chunmin C., et al.
Publicado: (2020)

A Comparison of Lipids and apoB in Asian Indians and Americans
por: Singh, Kavita, et al.
Publicado: (2021)

The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography
por: Song, Yongyan, et al.
Publicado: (2015)

Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions
por: Conlon, Donna M., et al.
Publicado: (2022)

ApoB100-LDL Acts as a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes
por: Skogsberg, Josefin, et al.
Publicado: (2008)

Prevalence of ApoB100 rs693 gene polymorphism in metabolic syndrome among female students at King Abdulaziz University
por: Alghamdi, Rana A., et al.
Publicado: (2021)

Ellagic Acid Suppresses ApoB Secretion and Enhances ApoA-1 Secretion from Human Hepatoma Cells, HepG2
por: Ieda, Ayana, et al.
Publicado: (2021)

Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice
por: Hoyk, Zsófia, et al.
Publicado: (2018)

HBV inhibits apoB production via the suppression of MTP expression
por: Wang, Fu-Bing, et al.
Publicado: (2011)

SAA is Found on ApoB-Containing Lipoproteins in Obese Diabetic Humans
por: Jahangiri, Anisa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_82eo8c6a0oe7laj9b68b6vgrg4