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The biological implications of Yin Yang 1 in the hallmarks of cancer

Tumorigenesis is a multistep process characterized by the acquisition of genetic and epigenetic alterations. During the course of malignancy development, tumor cells acquire several features that allow them to survive and adapt to the stress-related conditions of the tumor microenvironment. These pr...

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Autores principales: Meliala, Ian Timothy Sembiring, Hosea, Rendy, Kasim, Vivi, Wu, Shourong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086370/
https://www.ncbi.nlm.nih.gov/pubmed/32226547
http://dx.doi.org/10.7150/thno.43481
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author Meliala, Ian Timothy Sembiring
Hosea, Rendy
Kasim, Vivi
Wu, Shourong
author_facet Meliala, Ian Timothy Sembiring
Hosea, Rendy
Kasim, Vivi
Wu, Shourong
author_sort Meliala, Ian Timothy Sembiring
collection PubMed
description Tumorigenesis is a multistep process characterized by the acquisition of genetic and epigenetic alterations. During the course of malignancy development, tumor cells acquire several features that allow them to survive and adapt to the stress-related conditions of the tumor microenvironment. These properties, which are known as hallmarks of cancer, include uncontrolled cell proliferation, metabolic reprogramming, tumor angiogenesis, metastasis, and immune system evasion. Zinc-finger protein Yin Yang 1 (YY1) regulates numerous genes involved in cell death, cell cycle, cellular metabolism, and inflammatory response. YY1 is highly expressed in many cancers, whereby it is associated with cell proliferation, survival, and metabolic reprogramming. Furthermore, recent studies also have demonstrated the important role of YY1-related non-coding RNAs in acquiring cancer-specific characteristics. Therefore, these YY1-related non-coding RNAs are also crucial for YY1-mediated tumorigenesis. Herein, we summarize recent progress with respect to YY1 and its biological implications in the context of hallmarks of cancer.
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spelling pubmed-70863702020-03-27 The biological implications of Yin Yang 1 in the hallmarks of cancer Meliala, Ian Timothy Sembiring Hosea, Rendy Kasim, Vivi Wu, Shourong Theranostics Review Tumorigenesis is a multistep process characterized by the acquisition of genetic and epigenetic alterations. During the course of malignancy development, tumor cells acquire several features that allow them to survive and adapt to the stress-related conditions of the tumor microenvironment. These properties, which are known as hallmarks of cancer, include uncontrolled cell proliferation, metabolic reprogramming, tumor angiogenesis, metastasis, and immune system evasion. Zinc-finger protein Yin Yang 1 (YY1) regulates numerous genes involved in cell death, cell cycle, cellular metabolism, and inflammatory response. YY1 is highly expressed in many cancers, whereby it is associated with cell proliferation, survival, and metabolic reprogramming. Furthermore, recent studies also have demonstrated the important role of YY1-related non-coding RNAs in acquiring cancer-specific characteristics. Therefore, these YY1-related non-coding RNAs are also crucial for YY1-mediated tumorigenesis. Herein, we summarize recent progress with respect to YY1 and its biological implications in the context of hallmarks of cancer. Ivyspring International Publisher 2020-03-04 /pmc/articles/PMC7086370/ /pubmed/32226547 http://dx.doi.org/10.7150/thno.43481 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Meliala, Ian Timothy Sembiring
Hosea, Rendy
Kasim, Vivi
Wu, Shourong
The biological implications of Yin Yang 1 in the hallmarks of cancer
title The biological implications of Yin Yang 1 in the hallmarks of cancer
title_full The biological implications of Yin Yang 1 in the hallmarks of cancer
title_fullStr The biological implications of Yin Yang 1 in the hallmarks of cancer
title_full_unstemmed The biological implications of Yin Yang 1 in the hallmarks of cancer
title_short The biological implications of Yin Yang 1 in the hallmarks of cancer
title_sort biological implications of yin yang 1 in the hallmarks of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086370/
https://www.ncbi.nlm.nih.gov/pubmed/32226547
http://dx.doi.org/10.7150/thno.43481
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