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Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia

The mangrove ecosystem of Malaysia remains yet to be fully explored for potential microbes that produce biologically active metabolites. In the present study, a mangrove-derived Streptomyces sp. strain MUSC 14 previously isolated from the state of Pahang, Malaysia Peninsula, was studied for its pote...

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Autores principales: Kemung, Hefa Mangzira, Tan, Loh Teng-Hern, Chan, Kok-Gan, Ser, Hooi-Leng, Law, Jodi Woan-Fei, Lee, Learn-Han, Goh, Bey-Hing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086420/
https://www.ncbi.nlm.nih.gov/pubmed/32258133
http://dx.doi.org/10.1155/2020/6402607
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author Kemung, Hefa Mangzira
Tan, Loh Teng-Hern
Chan, Kok-Gan
Ser, Hooi-Leng
Law, Jodi Woan-Fei
Lee, Learn-Han
Goh, Bey-Hing
author_facet Kemung, Hefa Mangzira
Tan, Loh Teng-Hern
Chan, Kok-Gan
Ser, Hooi-Leng
Law, Jodi Woan-Fei
Lee, Learn-Han
Goh, Bey-Hing
author_sort Kemung, Hefa Mangzira
collection PubMed
description The mangrove ecosystem of Malaysia remains yet to be fully explored for potential microbes that produce biologically active metabolites. In the present study, a mangrove-derived Streptomyces sp. strain MUSC 14 previously isolated from the state of Pahang, Malaysia Peninsula, was studied for its potential in producing antioxidant metabolites. The identity of Streptomyces sp. strain MUSC14 was consistent with the genotypic and phenotypic characteristics of the Streptomyces genus. The antioxidant potential of Streptomyces sp. strain MUSC 14 was determined through screening of its methanolic extract against sets of antioxidant assays. The results were indicative of Streptomyces sp. strain MUSC 14 displaying strong antioxidant activity against ABTS, DPPH free radicals and metal chelating activity of 62.71 ± 3.30%, 24.71 ± 2.22%, and 55.82 ± 2.35%, respectively. The result of ferric reducing activity measured in terms of dose was equivalent to 2.35–2.45 μg of positive control ascorbic acid. Furthermore, there was a high correlation between the total phenolic content and the antioxidant activities with r = 0.979, r = 0.858, and r = 0.983 representing ABTS, DPPH, and metal chelation, respectively. Overall, the present study suggests that Streptomyces sp. strain MUSC 14 from mangrove forest soil has potential to produce antioxidant metabolites that can be further exploited for therapeutic application.
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spelling pubmed-70864202020-04-04 Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia Kemung, Hefa Mangzira Tan, Loh Teng-Hern Chan, Kok-Gan Ser, Hooi-Leng Law, Jodi Woan-Fei Lee, Learn-Han Goh, Bey-Hing Biomed Res Int Research Article The mangrove ecosystem of Malaysia remains yet to be fully explored for potential microbes that produce biologically active metabolites. In the present study, a mangrove-derived Streptomyces sp. strain MUSC 14 previously isolated from the state of Pahang, Malaysia Peninsula, was studied for its potential in producing antioxidant metabolites. The identity of Streptomyces sp. strain MUSC14 was consistent with the genotypic and phenotypic characteristics of the Streptomyces genus. The antioxidant potential of Streptomyces sp. strain MUSC 14 was determined through screening of its methanolic extract against sets of antioxidant assays. The results were indicative of Streptomyces sp. strain MUSC 14 displaying strong antioxidant activity against ABTS, DPPH free radicals and metal chelating activity of 62.71 ± 3.30%, 24.71 ± 2.22%, and 55.82 ± 2.35%, respectively. The result of ferric reducing activity measured in terms of dose was equivalent to 2.35–2.45 μg of positive control ascorbic acid. Furthermore, there was a high correlation between the total phenolic content and the antioxidant activities with r = 0.979, r = 0.858, and r = 0.983 representing ABTS, DPPH, and metal chelation, respectively. Overall, the present study suggests that Streptomyces sp. strain MUSC 14 from mangrove forest soil has potential to produce antioxidant metabolites that can be further exploited for therapeutic application. Hindawi 2020-03-11 /pmc/articles/PMC7086420/ /pubmed/32258133 http://dx.doi.org/10.1155/2020/6402607 Text en Copyright © 2020 Hefa Mangzira Kemung et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kemung, Hefa Mangzira
Tan, Loh Teng-Hern
Chan, Kok-Gan
Ser, Hooi-Leng
Law, Jodi Woan-Fei
Lee, Learn-Han
Goh, Bey-Hing
Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia
title Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia
title_full Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia
title_fullStr Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia
title_full_unstemmed Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia
title_short Antioxidant Activities of Streptomyces sp. strain MUSC 14 from Mangrove Forest Soil in Malaysia
title_sort antioxidant activities of streptomyces sp. strain musc 14 from mangrove forest soil in malaysia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086420/
https://www.ncbi.nlm.nih.gov/pubmed/32258133
http://dx.doi.org/10.1155/2020/6402607
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