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Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat

Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected wit...

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Detalles Bibliográficos
Autores principales: Michaels, Richard H, Myerowitz, Richard L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086508/
https://www.ncbi.nlm.nih.gov/pubmed/6308551
http://dx.doi.org/10.1203/00006450-198306000-00009
Descripción
Sumario:Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected with each of these viruses resulted in nasal HIB titers at least 100-fold higher than those for controls during the first 2 wk after HIB inoculation, and as much as 10,000-fold higher during the first week. Children with cough, sneezing, or rhinorrhea could be effective disseminators of HIB if they were as heavily and persistently colonized as these virus-infected animals.