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Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat

Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected wit...

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Detalles Bibliográficos
Autores principales: Michaels, Richard H, Myerowitz, Richard L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 1983
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086508/
https://www.ncbi.nlm.nih.gov/pubmed/6308551
http://dx.doi.org/10.1203/00006450-198306000-00009
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author Michaels, Richard H
Myerowitz, Richard L
author_facet Michaels, Richard H
Myerowitz, Richard L
author_sort Michaels, Richard H
collection PubMed
description Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected with each of these viruses resulted in nasal HIB titers at least 100-fold higher than those for controls during the first 2 wk after HIB inoculation, and as much as 10,000-fold higher during the first week. Children with cough, sneezing, or rhinorrhea could be effective disseminators of HIB if they were as heavily and persistently colonized as these virus-infected animals.
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spelling pubmed-70865082020-03-23 Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat Michaels, Richard H Myerowitz, Richard L Pediatr Res Article Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected with each of these viruses resulted in nasal HIB titers at least 100-fold higher than those for controls during the first 2 wk after HIB inoculation, and as much as 10,000-fold higher during the first week. Children with cough, sneezing, or rhinorrhea could be effective disseminators of HIB if they were as heavily and persistently colonized as these virus-infected animals. Nature Publishing Group US 1983 /pmc/articles/PMC7086508/ /pubmed/6308551 http://dx.doi.org/10.1203/00006450-198306000-00009 Text en © International Pediatrics Research Foundation, Inc. 1983 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Michaels, Richard H
Myerowitz, Richard L
Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
title Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
title_full Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
title_fullStr Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
title_full_unstemmed Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
title_short Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
title_sort viral enhancement of nasal colonization with haemophilus influenzae type b in the infant rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086508/
https://www.ncbi.nlm.nih.gov/pubmed/6308551
http://dx.doi.org/10.1203/00006450-198306000-00009
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