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Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat
Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected wit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
1983
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086508/ https://www.ncbi.nlm.nih.gov/pubmed/6308551 http://dx.doi.org/10.1203/00006450-198306000-00009 |
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author | Michaels, Richard H Myerowitz, Richard L |
author_facet | Michaels, Richard H Myerowitz, Richard L |
author_sort | Michaels, Richard H |
collection | PubMed |
description | Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected with each of these viruses resulted in nasal HIB titers at least 100-fold higher than those for controls during the first 2 wk after HIB inoculation, and as much as 10,000-fold higher during the first week. Children with cough, sneezing, or rhinorrhea could be effective disseminators of HIB if they were as heavily and persistently colonized as these virus-infected animals. |
format | Online Article Text |
id | pubmed-7086508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1983 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-70865082020-03-23 Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat Michaels, Richard H Myerowitz, Richard L Pediatr Res Article Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected with each of these viruses resulted in nasal HIB titers at least 100-fold higher than those for controls during the first 2 wk after HIB inoculation, and as much as 10,000-fold higher during the first week. Children with cough, sneezing, or rhinorrhea could be effective disseminators of HIB if they were as heavily and persistently colonized as these virus-infected animals. Nature Publishing Group US 1983 /pmc/articles/PMC7086508/ /pubmed/6308551 http://dx.doi.org/10.1203/00006450-198306000-00009 Text en © International Pediatrics Research Foundation, Inc. 1983 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Michaels, Richard H Myerowitz, Richard L Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat |
title | Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat |
title_full | Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat |
title_fullStr | Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat |
title_full_unstemmed | Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat |
title_short | Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat |
title_sort | viral enhancement of nasal colonization with haemophilus influenzae type b in the infant rat |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086508/ https://www.ncbi.nlm.nih.gov/pubmed/6308551 http://dx.doi.org/10.1203/00006450-198306000-00009 |
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