Low-pH-induced fusion of Vero cells infected with Junin virus

Junin virus (JV) infected Vero cells were used to investigate virus capacity to induce cell-cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH depe...

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Detalles Bibliográficos
Autores principales: Castilla, V., Mersich, S. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1996
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086872/
https://www.ncbi.nlm.nih.gov/pubmed/8774689
http://dx.doi.org/10.1007/BF01718832
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author Castilla, V.
Mersich, S. E.
author_facet Castilla, V.
Mersich, S. E.
author_sort Castilla, V.
collection PubMed
description Junin virus (JV) infected Vero cells were used to investigate virus capacity to induce cell-cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH dependence of their fusion activity. Neutralizing antibodies against the main viral glycoprotein (GP38) inhibited syncytium production and GP38 conformational changes in response to acid treatment were detected by an immunoprecipitation assay.
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spelling pubmed-70868722020-03-23 Low-pH-induced fusion of Vero cells infected with Junin virus Castilla, V. Mersich, S. E. Arch Virol Original Papers Junin virus (JV) infected Vero cells were used to investigate virus capacity to induce cell-cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH dependence of their fusion activity. Neutralizing antibodies against the main viral glycoprotein (GP38) inhibited syncytium production and GP38 conformational changes in response to acid treatment were detected by an immunoprecipitation assay. Springer-Verlag 1996 /pmc/articles/PMC7086872/ /pubmed/8774689 http://dx.doi.org/10.1007/BF01718832 Text en © Springer-Verlag 1996 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Papers
Castilla, V.
Mersich, S. E.
Low-pH-induced fusion of Vero cells infected with Junin virus
title Low-pH-induced fusion of Vero cells infected with Junin virus
title_full Low-pH-induced fusion of Vero cells infected with Junin virus
title_fullStr Low-pH-induced fusion of Vero cells infected with Junin virus
title_full_unstemmed Low-pH-induced fusion of Vero cells infected with Junin virus
title_short Low-pH-induced fusion of Vero cells infected with Junin virus
title_sort low-ph-induced fusion of vero cells infected with junin virus
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086872/
https://www.ncbi.nlm.nih.gov/pubmed/8774689
http://dx.doi.org/10.1007/BF01718832
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AT mersichse lowphinducedfusionofverocellsinfectedwithjuninvirus

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