Maternally-derived passive immunity to enterotropic mouse hepatitis virus

Maternally-derived antibody to enterotropic mouse hepatitis virus (MHV) strain Y was transferred to pups by both intrauterine (IgG) and lactogenic (IgA and IgG) routes. Antibody present in the gastric whey of pups suckling immune dams dropped to undetectable levels by weaning age (21 days post partu...

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Detalles Bibliográficos
Autor principal: Homberger, F. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1992
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086897/
https://www.ncbi.nlm.nih.gov/pubmed/1309638
http://dx.doi.org/10.1007/BF01321123
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author Homberger, F. R.
author_facet Homberger, F. R.
author_sort Homberger, F. R.
collection PubMed
description Maternally-derived antibody to enterotropic mouse hepatitis virus (MHV) strain Y was transferred to pups by both intrauterine (IgG) and lactogenic (IgA and IgG) routes. Antibody present in the gastric whey of pups suckling immune dams dropped to undetectable levels by weaning age (21 days post partum). MHV-specific IgG was found in the serum of passively immune pups up to 10 weeks of age. Immune dams transferred equal levels of antibody to 3 consecutive litters of pups, without evidence of decline. Immunoblots showed that IgA and IgG in whey and serum were directed against nucleoprotein N and glycoprotein S. MHV-specific IgM was not detected in any sample.
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spelling pubmed-70868972020-03-23 Maternally-derived passive immunity to enterotropic mouse hepatitis virus Homberger, F. R. Arch Virol Original Papers Maternally-derived antibody to enterotropic mouse hepatitis virus (MHV) strain Y was transferred to pups by both intrauterine (IgG) and lactogenic (IgA and IgG) routes. Antibody present in the gastric whey of pups suckling immune dams dropped to undetectable levels by weaning age (21 days post partum). MHV-specific IgG was found in the serum of passively immune pups up to 10 weeks of age. Immune dams transferred equal levels of antibody to 3 consecutive litters of pups, without evidence of decline. Immunoblots showed that IgA and IgG in whey and serum were directed against nucleoprotein N and glycoprotein S. MHV-specific IgM was not detected in any sample. Springer-Verlag 1992 /pmc/articles/PMC7086897/ /pubmed/1309638 http://dx.doi.org/10.1007/BF01321123 Text en © Springer-Verlag 1992 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Papers
Homberger, F. R.
Maternally-derived passive immunity to enterotropic mouse hepatitis virus
title Maternally-derived passive immunity to enterotropic mouse hepatitis virus
title_full Maternally-derived passive immunity to enterotropic mouse hepatitis virus
title_fullStr Maternally-derived passive immunity to enterotropic mouse hepatitis virus
title_full_unstemmed Maternally-derived passive immunity to enterotropic mouse hepatitis virus
title_short Maternally-derived passive immunity to enterotropic mouse hepatitis virus
title_sort maternally-derived passive immunity to enterotropic mouse hepatitis virus
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086897/
https://www.ncbi.nlm.nih.gov/pubmed/1309638
http://dx.doi.org/10.1007/BF01321123
work_keys_str_mv AT hombergerfr maternallyderivedpassiveimmunitytoenterotropicmousehepatitisvirus

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