The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review

 Feline aminopeptidase N (fAPN) has been shown to serve as a receptor for feline, canine, porcine and human coronaviruses. Our objective was to determine if fAPN can serve as a receptor for infectious bronchitis virus (IBV). Feline kidney cells that express fAPN and hamster kidney fibroblasts that d...

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Detalles Bibliográficos
Autores principales: Miguel, B., Pharr, G. T., Wang, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086910/
https://www.ncbi.nlm.nih.gov/pubmed/12417943
http://dx.doi.org/10.1007/s00705-002-0888-1
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author Miguel, B.
Pharr, G. T.
Wang, C.
author_facet Miguel, B.
Pharr, G. T.
Wang, C.
author_sort Miguel, B.
collection PubMed
description  Feline aminopeptidase N (fAPN) has been shown to serve as a receptor for feline, canine, porcine and human coronaviruses. Our objective was to determine if fAPN can serve as a receptor for infectious bronchitis virus (IBV). Feline kidney cells that express fAPN and hamster kidney fibroblasts that do not express fAPN were inoculated with IBV and monitored for replication by indirect fluorescent assay and confocal microscopy and in chicken embryonated eggs. The results showed that the feline cells were permissive to IBV but the hamster cells were not. The hamster cells became permissive to IBV after transfection with a fAPN cDNA suggesting that the feline APN molecule plays a role in IBV entry.
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spelling pubmed-70869102020-03-23 The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review Miguel, B. Pharr, G. T. Wang, C. Arch Virol Article  Feline aminopeptidase N (fAPN) has been shown to serve as a receptor for feline, canine, porcine and human coronaviruses. Our objective was to determine if fAPN can serve as a receptor for infectious bronchitis virus (IBV). Feline kidney cells that express fAPN and hamster kidney fibroblasts that do not express fAPN were inoculated with IBV and monitored for replication by indirect fluorescent assay and confocal microscopy and in chicken embryonated eggs. The results showed that the feline cells were permissive to IBV but the hamster cells were not. The hamster cells became permissive to IBV after transfection with a fAPN cDNA suggesting that the feline APN molecule plays a role in IBV entry. Springer-Verlag 2002 /pmc/articles/PMC7086910/ /pubmed/12417943 http://dx.doi.org/10.1007/s00705-002-0888-1 Text en © Springer-Verlag/Wien 2002 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Miguel, B.
Pharr, G. T.
Wang, C.
The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review
title The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review
title_full The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review
title_fullStr The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review
title_full_unstemmed The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review
title_short The role of feline aminopeptidase N as a receptor for infectious bronchitis virus : Brief Review
title_sort role of feline aminopeptidase n as a receptor for infectious bronchitis virus : brief review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086910/
https://www.ncbi.nlm.nih.gov/pubmed/12417943
http://dx.doi.org/10.1007/s00705-002-0888-1
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