Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China

Human metapneumovirus (hMPV) has recently been recognized as an important respiratory pathogen, especially in children. At present, our understanding of the characteristics of hMPV from China is very limited. Nasopharyngeal aspirates were taken from 310 hospitalized pediatric patients. Twenty (6.5%)...

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Autores principales: Li, Xiao-yan, Chen, Jin-ying, Kong, Mei, Su, Xu, Yi, Yan-ping, Zou, Ming, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2009
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086931/
https://www.ncbi.nlm.nih.gov/pubmed/19774338
http://dx.doi.org/10.1007/s00705-009-0492-8
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author Li, Xiao-yan
Chen, Jin-ying
Kong, Mei
Su, Xu
Yi, Yan-ping
Zou, Ming
Zhang, Hua
author_facet Li, Xiao-yan
Chen, Jin-ying
Kong, Mei
Su, Xu
Yi, Yan-ping
Zou, Ming
Zhang, Hua
author_sort Li, Xiao-yan
collection PubMed
description Human metapneumovirus (hMPV) has recently been recognized as an important respiratory pathogen, especially in children. At present, our understanding of the characteristics of hMPV from China is very limited. Nasopharyngeal aspirates were taken from 310 hospitalized pediatric patients. Twenty (6.5%) of them were infected with hMPV, and they all developed pneumonia. Sixty five percent (13/20) of the cases were under 12 months. Phylogenetic analysis of F gene fragments indicated that three sub-genotypes of hMPV(A2a/A2b, B1,B2) circulated in Tianjin and A2b was the predominant subtype. The Vero-E6 cell line was better than LLC-MK2 for hMPV isolation. Three hMPV strains were successfully isolated using the Vero-E6 cell line.
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spelling pubmed-70869312020-03-23 Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China Li, Xiao-yan Chen, Jin-ying Kong, Mei Su, Xu Yi, Yan-ping Zou, Ming Zhang, Hua Arch Virol Brief Report Human metapneumovirus (hMPV) has recently been recognized as an important respiratory pathogen, especially in children. At present, our understanding of the characteristics of hMPV from China is very limited. Nasopharyngeal aspirates were taken from 310 hospitalized pediatric patients. Twenty (6.5%) of them were infected with hMPV, and they all developed pneumonia. Sixty five percent (13/20) of the cases were under 12 months. Phylogenetic analysis of F gene fragments indicated that three sub-genotypes of hMPV(A2a/A2b, B1,B2) circulated in Tianjin and A2b was the predominant subtype. The Vero-E6 cell line was better than LLC-MK2 for hMPV isolation. Three hMPV strains were successfully isolated using the Vero-E6 cell line. Springer Vienna 2009-09-23 2009 /pmc/articles/PMC7086931/ /pubmed/19774338 http://dx.doi.org/10.1007/s00705-009-0492-8 Text en © Springer-Verlag 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Li, Xiao-yan
Chen, Jin-ying
Kong, Mei
Su, Xu
Yi, Yan-ping
Zou, Ming
Zhang, Hua
Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
title Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
title_full Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
title_fullStr Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
title_full_unstemmed Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
title_short Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
title_sort prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in tianjin, china
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086931/
https://www.ncbi.nlm.nih.gov/pubmed/19774338
http://dx.doi.org/10.1007/s00705-009-0492-8
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