The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae

The nucleoprotein-encoding gene (N) of murine hepatitis virus type 3 (MHV 3), from the Mill Hill strain, was cloned and sequenced. It was compared to gene N from other murine coronaviruses and was found to share more similarities with N sequences from MHV 1 and MHV JHM strains than with the publishe...

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Detalles Bibliográficos
Autores principales: Décimo, D., Philippe, H., Hadchouel, Michelle, Tardieu, M., Meunier-Rotival, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1993
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086934/
https://www.ncbi.nlm.nih.gov/pubmed/8390823
http://dx.doi.org/10.1007/BF01309660
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author Décimo, D.
Philippe, H.
Hadchouel, Michelle
Tardieu, M.
Meunier-Rotival, M.
author_facet Décimo, D.
Philippe, H.
Hadchouel, Michelle
Tardieu, M.
Meunier-Rotival, M.
author_sort Décimo, D.
collection PubMed
description The nucleoprotein-encoding gene (N) of murine hepatitis virus type 3 (MHV 3), from the Mill Hill strain, was cloned and sequenced. It was compared to gene N from other murine coronaviruses and was found to share more similarities with N sequences from MHV 1 and MHV JHM strains than with the published MHV 3 N sequence which is almost identical to MHV A59. We suggest that the evolution of some MHV N sequences resulted from a double recombination phenomenon between two ancestors. Furthermore, comparison of protein N from avian and mammalian coronaviruses leads to the hypothesis that horizontal transfer events of the virus from one host species to another have occurred.
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spelling pubmed-70869342020-03-23 The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae Décimo, D. Philippe, H. Hadchouel, Michelle Tardieu, M. Meunier-Rotival, M. Arch Virol Original Papers The nucleoprotein-encoding gene (N) of murine hepatitis virus type 3 (MHV 3), from the Mill Hill strain, was cloned and sequenced. It was compared to gene N from other murine coronaviruses and was found to share more similarities with N sequences from MHV 1 and MHV JHM strains than with the published MHV 3 N sequence which is almost identical to MHV A59. We suggest that the evolution of some MHV N sequences resulted from a double recombination phenomenon between two ancestors. Furthermore, comparison of protein N from avian and mammalian coronaviruses leads to the hypothesis that horizontal transfer events of the virus from one host species to another have occurred. Springer-Verlag 1993 /pmc/articles/PMC7086934/ /pubmed/8390823 http://dx.doi.org/10.1007/BF01309660 Text en © Springer-Verlag 1993 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Papers
Décimo, D.
Philippe, H.
Hadchouel, Michelle
Tardieu, M.
Meunier-Rotival, M.
The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae
title The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae
title_full The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae
title_fullStr The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae
title_full_unstemmed The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae
title_short The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution inCoronaviridae
title_sort gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution incoronaviridae
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086934/
https://www.ncbi.nlm.nih.gov/pubmed/8390823
http://dx.doi.org/10.1007/BF01309660
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