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Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
In 2012, a novel human coronavirus emerged and was tentatively named “Middle East respiratory syndrome coronavirus” (MERS-CoV). The high mortality rate of MERS-CoV focused attention on the ecology of the virus. It has been found that MERS-CoV belongs to the group C lineage of the genus Betacoronavir...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Vienna
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086939/ https://www.ncbi.nlm.nih.gov/pubmed/24515532 http://dx.doi.org/10.1007/s00705-014-1995-5 |
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author | Abdel-Moneim, Ahmed S. |
author_facet | Abdel-Moneim, Ahmed S. |
author_sort | Abdel-Moneim, Ahmed S. |
collection | PubMed |
description | In 2012, a novel human coronavirus emerged and was tentatively named “Middle East respiratory syndrome coronavirus” (MERS-CoV). The high mortality rate of MERS-CoV focused attention on the ecology of the virus. It has been found that MERS-CoV belongs to the group C lineage of the genus Betacoronavirus. Coronavirus surveillance studies in different populations of bats have suggested that they are probable reservoirs for this novel virus, and phylogenetic analysis of both the spike (S1) and RNA-dependent RNA polymerase proteins of MERS-CoV have revealed that it is related to bat viruses. Recently, the MERS-CoV and its neutralizing antibodies were detected in dromedary camels. Despite the limited number of reported cases of person-to-person transmission, the rapid evolution of the virus poses a continuous threat to humans worldwide. This paper reviews the current state of knowledge regarding the virology, clinical spectrum, evolution, diagnosis and treatment of MERS-CoV infections. |
format | Online Article Text |
id | pubmed-7086939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-70869392020-03-23 Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations Abdel-Moneim, Ahmed S. Arch Virol Brief Review In 2012, a novel human coronavirus emerged and was tentatively named “Middle East respiratory syndrome coronavirus” (MERS-CoV). The high mortality rate of MERS-CoV focused attention on the ecology of the virus. It has been found that MERS-CoV belongs to the group C lineage of the genus Betacoronavirus. Coronavirus surveillance studies in different populations of bats have suggested that they are probable reservoirs for this novel virus, and phylogenetic analysis of both the spike (S1) and RNA-dependent RNA polymerase proteins of MERS-CoV have revealed that it is related to bat viruses. Recently, the MERS-CoV and its neutralizing antibodies were detected in dromedary camels. Despite the limited number of reported cases of person-to-person transmission, the rapid evolution of the virus poses a continuous threat to humans worldwide. This paper reviews the current state of knowledge regarding the virology, clinical spectrum, evolution, diagnosis and treatment of MERS-CoV infections. Springer Vienna 2014-02-11 2014 /pmc/articles/PMC7086939/ /pubmed/24515532 http://dx.doi.org/10.1007/s00705-014-1995-5 Text en © Springer-Verlag Wien 2014 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Brief Review Abdel-Moneim, Ahmed S. Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations |
title | Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations |
title_full | Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations |
title_fullStr | Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations |
title_full_unstemmed | Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations |
title_short | Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations |
title_sort | middle east respiratory syndrome coronavirus (mers-cov): evidence and speculations |
topic | Brief Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086939/ https://www.ncbi.nlm.nih.gov/pubmed/24515532 http://dx.doi.org/10.1007/s00705-014-1995-5 |
work_keys_str_mv | AT abdelmoneimahmeds middleeastrespiratorysyndromecoronavirusmerscovevidenceandspeculations |