Cargando…

Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations

In 2012, a novel human coronavirus emerged and was tentatively named “Middle East respiratory syndrome coronavirus” (MERS-CoV). The high mortality rate of MERS-CoV focused attention on the ecology of the virus. It has been found that MERS-CoV belongs to the group C lineage of the genus Betacoronavir...

Descripción completa

Detalles Bibliográficos
Autor principal: Abdel-Moneim, Ahmed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086939/
https://www.ncbi.nlm.nih.gov/pubmed/24515532
http://dx.doi.org/10.1007/s00705-014-1995-5
_version_ 1783509230813184000
author Abdel-Moneim, Ahmed S.
author_facet Abdel-Moneim, Ahmed S.
author_sort Abdel-Moneim, Ahmed S.
collection PubMed
description In 2012, a novel human coronavirus emerged and was tentatively named “Middle East respiratory syndrome coronavirus” (MERS-CoV). The high mortality rate of MERS-CoV focused attention on the ecology of the virus. It has been found that MERS-CoV belongs to the group C lineage of the genus Betacoronavirus. Coronavirus surveillance studies in different populations of bats have suggested that they are probable reservoirs for this novel virus, and phylogenetic analysis of both the spike (S1) and RNA-dependent RNA polymerase proteins of MERS-CoV have revealed that it is related to bat viruses. Recently, the MERS-CoV and its neutralizing antibodies were detected in dromedary camels. Despite the limited number of reported cases of person-to-person transmission, the rapid evolution of the virus poses a continuous threat to humans worldwide. This paper reviews the current state of knowledge regarding the virology, clinical spectrum, evolution, diagnosis and treatment of MERS-CoV infections.
format Online
Article
Text
id pubmed-7086939
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-70869392020-03-23 Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations Abdel-Moneim, Ahmed S. Arch Virol Brief Review In 2012, a novel human coronavirus emerged and was tentatively named “Middle East respiratory syndrome coronavirus” (MERS-CoV). The high mortality rate of MERS-CoV focused attention on the ecology of the virus. It has been found that MERS-CoV belongs to the group C lineage of the genus Betacoronavirus. Coronavirus surveillance studies in different populations of bats have suggested that they are probable reservoirs for this novel virus, and phylogenetic analysis of both the spike (S1) and RNA-dependent RNA polymerase proteins of MERS-CoV have revealed that it is related to bat viruses. Recently, the MERS-CoV and its neutralizing antibodies were detected in dromedary camels. Despite the limited number of reported cases of person-to-person transmission, the rapid evolution of the virus poses a continuous threat to humans worldwide. This paper reviews the current state of knowledge regarding the virology, clinical spectrum, evolution, diagnosis and treatment of MERS-CoV infections. Springer Vienna 2014-02-11 2014 /pmc/articles/PMC7086939/ /pubmed/24515532 http://dx.doi.org/10.1007/s00705-014-1995-5 Text en © Springer-Verlag Wien 2014 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Review
Abdel-Moneim, Ahmed S.
Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
title Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
title_full Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
title_fullStr Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
title_full_unstemmed Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
title_short Middle East respiratory syndrome coronavirus (MERS-CoV): evidence and speculations
title_sort middle east respiratory syndrome coronavirus (mers-cov): evidence and speculations
topic Brief Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086939/
https://www.ncbi.nlm.nih.gov/pubmed/24515532
http://dx.doi.org/10.1007/s00705-014-1995-5
work_keys_str_mv AT abdelmoneimahmeds middleeastrespiratorysyndromecoronavirusmerscovevidenceandspeculations