Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication

In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HH...

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Detalles Bibliográficos
Autores principales: Li, Lingyun, Gu, Bin, Zhou, Feng, Chi, Jing, Feng, Dongju, Xie, Fangyi, Wang, Fang, Ma, Changyan, Li, Meng, Wang, Jinfeng, Yao, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086940/
https://www.ncbi.nlm.nih.gov/pubmed/24013234
http://dx.doi.org/10.1007/s00705-013-1826-0
Descripción
Sumario:In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.

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