Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication

In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HH...

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Autores principales: Li, Lingyun, Gu, Bin, Zhou, Feng, Chi, Jing, Feng, Dongju, Xie, Fangyi, Wang, Fang, Ma, Changyan, Li, Meng, Wang, Jinfeng, Yao, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086940/
https://www.ncbi.nlm.nih.gov/pubmed/24013234
http://dx.doi.org/10.1007/s00705-013-1826-0
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author Li, Lingyun
Gu, Bin
Zhou, Feng
Chi, Jing
Feng, Dongju
Xie, Fangyi
Wang, Fang
Ma, Changyan
Li, Meng
Wang, Jinfeng
Yao, Kun
author_facet Li, Lingyun
Gu, Bin
Zhou, Feng
Chi, Jing
Feng, Dongju
Xie, Fangyi
Wang, Fang
Ma, Changyan
Li, Meng
Wang, Jinfeng
Yao, Kun
author_sort Li, Lingyun
collection PubMed
description In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.
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spelling pubmed-70869402020-03-23 Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication Li, Lingyun Gu, Bin Zhou, Feng Chi, Jing Feng, Dongju Xie, Fangyi Wang, Fang Ma, Changyan Li, Meng Wang, Jinfeng Yao, Kun Arch Virol Brief Report In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication. Springer Vienna 2013-09-08 2014 /pmc/articles/PMC7086940/ /pubmed/24013234 http://dx.doi.org/10.1007/s00705-013-1826-0 Text en © Springer-Verlag Wien 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Li, Lingyun
Gu, Bin
Zhou, Feng
Chi, Jing
Feng, Dongju
Xie, Fangyi
Wang, Fang
Ma, Changyan
Li, Meng
Wang, Jinfeng
Yao, Kun
Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
title Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
title_full Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
title_fullStr Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
title_full_unstemmed Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
title_short Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
title_sort cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086940/
https://www.ncbi.nlm.nih.gov/pubmed/24013234
http://dx.doi.org/10.1007/s00705-013-1826-0
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