Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus

Porcine epidemic diarrhea (PED) is a contagious viral disease in pigs, caused by the coronavirus porcine epidemic diarrhea virus (PEDV). PEDV infection results in significant mortality in piglets in unvaccinated herds. Like many others RNA viruses, PEDV has high evolutionary rate and is prone to gen...

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Autores principales: Nefedeva, Mariia, Titov, Ilya, Malogolovkin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2019
Materias:
Annotated Sequence Record
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086971/
https://www.ncbi.nlm.nih.gov/pubmed/30725181
http://dx.doi.org/10.1007/s00705-019-04166-4
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author Nefedeva, Mariia
Titov, Ilya
Malogolovkin, Alexander
author_facet Nefedeva, Mariia
Titov, Ilya
Malogolovkin, Alexander
author_sort Nefedeva, Mariia
collection PubMed
description Porcine epidemic diarrhea (PED) is a contagious viral disease in pigs, caused by the coronavirus porcine epidemic diarrhea virus (PEDV). PEDV infection results in significant mortality in piglets in unvaccinated herds. Like many others RNA viruses, PEDV has high evolutionary rate and is prone to genetic mutations. In this study, we analyzed the complete genome sequence of the recently sequenced isolate PEDV/Belgorod/dom/2008. A recombination event in S gene of PEDV/Belgorod/dom/2008 was detected. Pairwise identity analysis of the whole genome sequences revealed that PEDV/Belgorod/dom/2008 is an intermediate between PEDV and transmissible gastroenteritis virus (TGEV) strains. These results can be used for further analysis of the evolutionary variability, prevalence, and epidemiology of the porcine epidemic diarrhea virus.
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spelling pubmed-70869712020-03-23 Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus Nefedeva, Mariia Titov, Ilya Malogolovkin, Alexander Arch Virol Annotated Sequence Record Porcine epidemic diarrhea (PED) is a contagious viral disease in pigs, caused by the coronavirus porcine epidemic diarrhea virus (PEDV). PEDV infection results in significant mortality in piglets in unvaccinated herds. Like many others RNA viruses, PEDV has high evolutionary rate and is prone to genetic mutations. In this study, we analyzed the complete genome sequence of the recently sequenced isolate PEDV/Belgorod/dom/2008. A recombination event in S gene of PEDV/Belgorod/dom/2008 was detected. Pairwise identity analysis of the whole genome sequences revealed that PEDV/Belgorod/dom/2008 is an intermediate between PEDV and transmissible gastroenteritis virus (TGEV) strains. These results can be used for further analysis of the evolutionary variability, prevalence, and epidemiology of the porcine epidemic diarrhea virus. Springer Vienna 2019-02-06 2019 /pmc/articles/PMC7086971/ /pubmed/30725181 http://dx.doi.org/10.1007/s00705-019-04166-4 Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Annotated Sequence Record
Nefedeva, Mariia
Titov, Ilya
Malogolovkin, Alexander
Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
title Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
title_full Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
title_fullStr Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
title_full_unstemmed Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
title_short Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
title_sort molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus
topic Annotated Sequence Record
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086971/
https://www.ncbi.nlm.nih.gov/pubmed/30725181
http://dx.doi.org/10.1007/s00705-019-04166-4
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