Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China

Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively. The recombinant dengue virus was further confirmed by phylogenetic analysis based o...

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Detalles Bibliográficos
Autores principales: Chen, S.-P., Yu, M., Jiang, T., Deng, Y.-Q., Qin, C.-F., Han, J.-F., Qin, E.-D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2008
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087008/
https://www.ncbi.nlm.nih.gov/pubmed/18446424
http://dx.doi.org/10.1007/s00705-008-0090-1
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author Chen, S.-P.
Yu, M.
Jiang, T.
Deng, Y.-Q.
Qin, C.-F.
Han, J.-F.
Qin, E.-D.
author_facet Chen, S.-P.
Yu, M.
Jiang, T.
Deng, Y.-Q.
Qin, C.-F.
Han, J.-F.
Qin, E.-D.
author_sort Chen, S.-P.
collection PubMed
description Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively. The recombinant dengue virus was further confirmed by phylogenetic analysis based on its recombination and non-recombination regions. This appears to be the first study to confirm the existence of three recombination regions in a single dengue virus isolate and to report recombination between parent virus strains isolated from the same geographic area (Guangdong province, China). It is also the first to report breakpoints within the NS3 gene of dengue viruses.
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spelling pubmed-70870082020-03-23 Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China Chen, S.-P. Yu, M. Jiang, T. Deng, Y.-Q. Qin, C.-F. Han, J.-F. Qin, E.-D. Arch Virol Brief Report Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively. The recombinant dengue virus was further confirmed by phylogenetic analysis based on its recombination and non-recombination regions. This appears to be the first study to confirm the existence of three recombination regions in a single dengue virus isolate and to report recombination between parent virus strains isolated from the same geographic area (Guangdong province, China). It is also the first to report breakpoints within the NS3 gene of dengue viruses. Springer Vienna 2008-04-30 2008 /pmc/articles/PMC7087008/ /pubmed/18446424 http://dx.doi.org/10.1007/s00705-008-0090-1 Text en © Springer-Verlag 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Chen, S.-P.
Yu, M.
Jiang, T.
Deng, Y.-Q.
Qin, C.-F.
Han, J.-F.
Qin, E.-D.
Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
title Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
title_full Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
title_fullStr Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
title_full_unstemmed Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
title_short Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
title_sort identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in guangdong province, china
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087008/
https://www.ncbi.nlm.nih.gov/pubmed/18446424
http://dx.doi.org/10.1007/s00705-008-0090-1
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