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Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a
Analyses of transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) isolates have suggested that tropism and pathogenicity are influenced by the spike protein and ORF 3. In general, enteric viruses (TGEV) have been shown to contain intact spike and ORF 3 genes, whilst r...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087079/ https://www.ncbi.nlm.nih.gov/pubmed/10365166 http://dx.doi.org/10.1007/s007050050541 |
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author | McGoldrick, A. Lowings, J. P. Paton, D. J. |
author_facet | McGoldrick, A. Lowings, J. P. Paton, D. J. |
author_sort | McGoldrick, A. |
collection | PubMed |
description | Analyses of transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) isolates have suggested that tropism and pathogenicity are influenced by the spike protein and ORF 3. In general, enteric viruses (TGEV) have been shown to contain intact spike and ORF 3 genes, whilst respiratory isolates (PRCV) have major deletions within both regions. Virulence has been correlated to a functional ORF 3. Here, sequence analysis of a recent isolate of virulent TGEV, revealed a variant with an intact spike gene, but a large deletion in ORF 3a. This suggests that ORF 3a is not essential for enteric virulence. |
format | Online Article Text |
id | pubmed-7087079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70870792020-03-23 Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a McGoldrick, A. Lowings, J. P. Paton, D. J. Arch Virol Brief Report Analyses of transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) isolates have suggested that tropism and pathogenicity are influenced by the spike protein and ORF 3. In general, enteric viruses (TGEV) have been shown to contain intact spike and ORF 3 genes, whilst respiratory isolates (PRCV) have major deletions within both regions. Virulence has been correlated to a functional ORF 3. Here, sequence analysis of a recent isolate of virulent TGEV, revealed a variant with an intact spike gene, but a large deletion in ORF 3a. This suggests that ORF 3a is not essential for enteric virulence. Springer-Verlag 2014-05-18 1999 /pmc/articles/PMC7087079/ /pubmed/10365166 http://dx.doi.org/10.1007/s007050050541 Text en © Springer-Verlag 1999 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Brief Report McGoldrick, A. Lowings, J. P. Paton, D. J. Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a |
title | Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a |
title_full | Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a |
title_fullStr | Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a |
title_full_unstemmed | Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a |
title_short | Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a |
title_sort | characterisation of a recent virulent transmissible gastroenteritis virus from britain with a deleted orf 3a |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087079/ https://www.ncbi.nlm.nih.gov/pubmed/10365166 http://dx.doi.org/10.1007/s007050050541 |
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