New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017

Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one co...

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Autores principales: Su, Yunfang, Hou, Yixuan, Prarat, Melanie, Zhang, Yan, Wang, Qiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087112/
https://www.ncbi.nlm.nih.gov/pubmed/29789941
http://dx.doi.org/10.1007/s00705-018-3874-y
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author Su, Yunfang
Hou, Yixuan
Prarat, Melanie
Zhang, Yan
Wang, Qiuhong
author_facet Su, Yunfang
Hou, Yixuan
Prarat, Melanie
Zhang, Yan
Wang, Qiuhong
author_sort Su, Yunfang
collection PubMed
description Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD-del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes.
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spelling pubmed-70871122020-03-23 New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017 Su, Yunfang Hou, Yixuan Prarat, Melanie Zhang, Yan Wang, Qiuhong Arch Virol Brief Report Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD-del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes. Springer Vienna 2018-05-22 2018 /pmc/articles/PMC7087112/ /pubmed/29789941 http://dx.doi.org/10.1007/s00705-018-3874-y Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Su, Yunfang
Hou, Yixuan
Prarat, Melanie
Zhang, Yan
Wang, Qiuhong
New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017
title New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017
title_full New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017
title_fullStr New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017
title_full_unstemmed New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017
title_short New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017
title_sort new variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the united states, 2016-2017
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087112/
https://www.ncbi.nlm.nih.gov/pubmed/29789941
http://dx.doi.org/10.1007/s00705-018-3874-y
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