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Aetiology of community-acquired pneumonia in children treated in hospital
Viral and bacterial antigen and antibody assays were prospectively applied to study the microbial actiology of community-acquired pneumonia in 195 hospitalised children during a surveillance period of 12 months. A viral infection alone was indicated in 37 (19%), a bacterial infection alone in 30 (15...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087117/ https://www.ncbi.nlm.nih.gov/pubmed/8444202 http://dx.doi.org/10.1007/BF02072512 |
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author | Korppi, M. Heiskanen-Kosma, T. Jalonen, E. Saikku, P. Leinonen, M. Halonen, P. Mäkela, P. H. |
author_facet | Korppi, M. Heiskanen-Kosma, T. Jalonen, E. Saikku, P. Leinonen, M. Halonen, P. Mäkela, P. H. |
author_sort | Korppi, M. |
collection | PubMed |
description | Viral and bacterial antigen and antibody assays were prospectively applied to study the microbial actiology of community-acquired pneumonia in 195 hospitalised children during a surveillance period of 12 months. A viral infection alone was indicated in 37 (19%), a bacterial infection alone in 30 (15%) and a mixed viral-bacterial infection in 32 (16%) patients. Thus, 46% of the 69 patients with viral infection and 52% of the 62 patients with bacterial infection had a mixed viral and bacterial aetiology. Respiratory syncytial virus (RSV) was identified in 52 patients andStreptococcus pneumoniae in 41 patients. The next common agents in order were non-classifiedHaemophilus influenzae (17 cases), adenoviruses (10 cases) andChlamydia species (8 cases). The diagnosis of an RSV infection was based on detecting viral antigen in nasopharyngeal secretions in 79% of the cases. Pneumococcal infections were in most cases identified by antibody assays; in 39% they were indicated by demonstrating pneumococcal antigen in acute phase serum. An alveolar infiltrate was present in 53 (27%) and an interstitial infiltrate in 108 (55%) of the 195 patients. The remaining 34 patients had probable pneumonia. C-reactive protein (CRP), erythrocyte sedimentation rate and total white blood cell count were elevated in 25%, 40% and 36% of the patients, respectively, CRP was more often elevated in patients with bacterial infection alone than in those with viral or mixed viral-bacterial infections. No other correlation was seen between the radiological or laboratory findings and serologically identified viral, bacterial or mixed viralbacterial infections. By using a comprehensive serological panel, the causative agent could be found in over 50% of patients with pneumonia. We conclude that RSV and pneumococcus are the two most common organisms causing pneumonia in children. Our results suggest that mixed viral-bacterial aetiology is common in lower respiratory tract infections affecting children. |
format | Online Article Text |
id | pubmed-7087117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70871172020-03-23 Aetiology of community-acquired pneumonia in children treated in hospital Korppi, M. Heiskanen-Kosma, T. Jalonen, E. Saikku, P. Leinonen, M. Halonen, P. Mäkela, P. H. Eur J Pediatr Infectious Diseases Viral and bacterial antigen and antibody assays were prospectively applied to study the microbial actiology of community-acquired pneumonia in 195 hospitalised children during a surveillance period of 12 months. A viral infection alone was indicated in 37 (19%), a bacterial infection alone in 30 (15%) and a mixed viral-bacterial infection in 32 (16%) patients. Thus, 46% of the 69 patients with viral infection and 52% of the 62 patients with bacterial infection had a mixed viral and bacterial aetiology. Respiratory syncytial virus (RSV) was identified in 52 patients andStreptococcus pneumoniae in 41 patients. The next common agents in order were non-classifiedHaemophilus influenzae (17 cases), adenoviruses (10 cases) andChlamydia species (8 cases). The diagnosis of an RSV infection was based on detecting viral antigen in nasopharyngeal secretions in 79% of the cases. Pneumococcal infections were in most cases identified by antibody assays; in 39% they were indicated by demonstrating pneumococcal antigen in acute phase serum. An alveolar infiltrate was present in 53 (27%) and an interstitial infiltrate in 108 (55%) of the 195 patients. The remaining 34 patients had probable pneumonia. C-reactive protein (CRP), erythrocyte sedimentation rate and total white blood cell count were elevated in 25%, 40% and 36% of the patients, respectively, CRP was more often elevated in patients with bacterial infection alone than in those with viral or mixed viral-bacterial infections. No other correlation was seen between the radiological or laboratory findings and serologically identified viral, bacterial or mixed viralbacterial infections. By using a comprehensive serological panel, the causative agent could be found in over 50% of patients with pneumonia. We conclude that RSV and pneumococcus are the two most common organisms causing pneumonia in children. Our results suggest that mixed viral-bacterial aetiology is common in lower respiratory tract infections affecting children. Springer-Verlag 1993 /pmc/articles/PMC7087117/ /pubmed/8444202 http://dx.doi.org/10.1007/BF02072512 Text en © Springer-Verlag 1993 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Infectious Diseases Korppi, M. Heiskanen-Kosma, T. Jalonen, E. Saikku, P. Leinonen, M. Halonen, P. Mäkela, P. H. Aetiology of community-acquired pneumonia in children treated in hospital |
title | Aetiology of community-acquired pneumonia in children treated in hospital |
title_full | Aetiology of community-acquired pneumonia in children treated in hospital |
title_fullStr | Aetiology of community-acquired pneumonia in children treated in hospital |
title_full_unstemmed | Aetiology of community-acquired pneumonia in children treated in hospital |
title_short | Aetiology of community-acquired pneumonia in children treated in hospital |
title_sort | aetiology of community-acquired pneumonia in children treated in hospital |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087117/ https://www.ncbi.nlm.nih.gov/pubmed/8444202 http://dx.doi.org/10.1007/BF02072512 |
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