Experimental infection of inbred BALB/c and A/J mice with Massachusetts and Brazilian strains of infectious bronchitis virus (IBV)

The ability of avian coronaviruses to replicate in mice was investigated to investigate interspecies transmission. Two inbred mouse strains (BALB/c and A/J) with different genetic backgrounds were inoculated with the avian coronavirus strains Mass and BR-I and monitored for at least 10 days. Analysi...

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Detalles Bibliográficos
Autores principales: Martini, Matheus C., Gameiro, Jacy, Cardoso, Tereza Cristina, Caserta, Leonardo C., Gualberto, Ana Carolina M., Keid, Lara Borges, Oliveira, Trícia M. F. de S., dos Santos, Marcia M. A. B., Arns, Clarice W., Ferreira, Helena L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087133/
https://www.ncbi.nlm.nih.gov/pubmed/25951972
http://dx.doi.org/10.1007/s00705-015-2443-x
Descripción
Sumario:The ability of avian coronaviruses to replicate in mice was investigated to investigate interspecies transmission. Two inbred mouse strains (BALB/c and A/J) with different genetic backgrounds were inoculated with the avian coronavirus strains Mass and BR-I and monitored for at least 10 days. Analysis of viral RNA, histopathological examinations, immunohistochemistry and serology were performed. After virus inoculation, neither clinical signs nor evident gross lesions were observed. Viral RNA, histopathological changes, and viral nucleoprotein were observed in the lung, trachea and sinus of all inoculated mice. Our study demonstrates the importance of elucidating the epidemiology of coronaviruses, including in rodents that are pests in poultry production.

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