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Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71

Hand–foot–mouth disease due to enterovirus 71 (EV71) and coxsackievirus A16 (CA16) has recently caused large outbreaks in mainland China in 2008. We performed complete genome sequencing on two EV71 (SZ/HK08-5 and SZ/HK08-6) and two CA16 (SZ/HK08-3 and SZ/HK08-7) strains from patients in Shenzhen, Ch...

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Autores principales: Yip, Cyril C. Y., Lau, Susanna K. P., Zhou, Boping, Zhang, Ming-Xia, Tsoi, Hoi-Wah, Chan, Kwok-Hung, Chen, Xin-Chun, Woo, Patrick C. Y., Yuen, Kwok-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087135/
https://www.ncbi.nlm.nih.gov/pubmed/20549263
http://dx.doi.org/10.1007/s00705-010-0722-0
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author Yip, Cyril C. Y.
Lau, Susanna K. P.
Zhou, Boping
Zhang, Ming-Xia
Tsoi, Hoi-Wah
Chan, Kwok-Hung
Chen, Xin-Chun
Woo, Patrick C. Y.
Yuen, Kwok-Yung
author_facet Yip, Cyril C. Y.
Lau, Susanna K. P.
Zhou, Boping
Zhang, Ming-Xia
Tsoi, Hoi-Wah
Chan, Kwok-Hung
Chen, Xin-Chun
Woo, Patrick C. Y.
Yuen, Kwok-Yung
author_sort Yip, Cyril C. Y.
collection PubMed
description Hand–foot–mouth disease due to enterovirus 71 (EV71) and coxsackievirus A16 (CA16) has recently caused large outbreaks in mainland China in 2008. We performed complete genome sequencing on two EV71 (SZ/HK08-5 and SZ/HK08-6) and two CA16 (SZ/HK08-3 and SZ/HK08-7) strains from patients in Shenzhen, China. Phylogenetic, similarity plot and bootscan analyses revealed recombination between EV71 genotypes B and C at the 2A–2B junction, and between EV71 genotype B and CA16 strain G-10 in the 3C region for EV71 strains. A similar phenomenon was also found upon further gene sequencing with other EV71 strains. Recombination between CA16 strain G-10 and EV71 genotype A at the 2A–2B junction was also observed for CA16 strains. The present “double-recombinant” EV71 strains circulating in China and other EV71 subgenotype “C4” strains represent an additional genotype, D. CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-010-0722-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-70871352020-03-23 Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71 Yip, Cyril C. Y. Lau, Susanna K. P. Zhou, Boping Zhang, Ming-Xia Tsoi, Hoi-Wah Chan, Kwok-Hung Chen, Xin-Chun Woo, Patrick C. Y. Yuen, Kwok-Yung Arch Virol Original Article Hand–foot–mouth disease due to enterovirus 71 (EV71) and coxsackievirus A16 (CA16) has recently caused large outbreaks in mainland China in 2008. We performed complete genome sequencing on two EV71 (SZ/HK08-5 and SZ/HK08-6) and two CA16 (SZ/HK08-3 and SZ/HK08-7) strains from patients in Shenzhen, China. Phylogenetic, similarity plot and bootscan analyses revealed recombination between EV71 genotypes B and C at the 2A–2B junction, and between EV71 genotype B and CA16 strain G-10 in the 3C region for EV71 strains. A similar phenomenon was also found upon further gene sequencing with other EV71 strains. Recombination between CA16 strain G-10 and EV71 genotype A at the 2A–2B junction was also observed for CA16 strains. The present “double-recombinant” EV71 strains circulating in China and other EV71 subgenotype “C4” strains represent an additional genotype, D. CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-010-0722-0) contains supplementary material, which is available to authorized users. Springer Vienna 2010-06-13 2010 /pmc/articles/PMC7087135/ /pubmed/20549263 http://dx.doi.org/10.1007/s00705-010-0722-0 Text en © Springer-Verlag 2010 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Yip, Cyril C. Y.
Lau, Susanna K. P.
Zhou, Boping
Zhang, Ming-Xia
Tsoi, Hoi-Wah
Chan, Kwok-Hung
Chen, Xin-Chun
Woo, Patrick C. Y.
Yuen, Kwok-Yung
Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
title Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
title_full Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
title_fullStr Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
title_full_unstemmed Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
title_short Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
title_sort emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype d originating from southern china: first evidence for combination of intratypic and intertypic recombination events in ev71
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087135/
https://www.ncbi.nlm.nih.gov/pubmed/20549263
http://dx.doi.org/10.1007/s00705-010-0722-0
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