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Treatment of multiple sclerosis with anti-measles cow colostrum

Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobu...

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Autores principales: Ebina, T., Sato, A., Umezu, K., Aso, H., Ishida, N., Seki, H., Tsukamoto, T., Takase, S., Hoshi, S., Ohta, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1984
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087162/
https://www.ncbi.nlm.nih.gov/pubmed/6493135
http://dx.doi.org/10.1007/BF02124822
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author Ebina, T.
Sato, A.
Umezu, K.
Aso, H.
Ishida, N.
Seki, H.
Tsukamoto, T.
Takase, S.
Hoshi, S.
Ohta, M.
author_facet Ebina, T.
Sato, A.
Umezu, K.
Aso, H.
Ishida, N.
Seki, H.
Tsukamoto, T.
Takase, S.
Hoshi, S.
Ohta, M.
author_sort Ebina, T.
collection PubMed
description Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobulin resistant to proteases. This colostrum was orally administered to patients with MS to investigate its effect on the course of the disease. Measles-positive antibody colostrum was orally administered every morning to 15 patients with MS at a daily dosage of 100 ml for 30 days. Similarly, measles-negative antibody (< 8) control colostrum was orally administered to 5 patients. As a clinical assessment, disability scores developed by the International Federation of Multiple Sclerosis Societies were used. As a result, of 7 high NT titre (512–5120) anti-measles colostrum recipients 5 patients improved and 2 remained unchanged. Among 8 low NT titre (8–32) anti-measles colostrum recipients 5 patients improved and 3 remained unchanged. However, of 5 negative NT titre (< 8) colostrum recipients 2 patients remained unchanged and 3 worsened. No side-effects were observed in colostrum recipients. These findings suggest the efficacy of orally administered anti-measles colostrum in improving the condition of MS patients (P < 0.05).
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spelling pubmed-70871622020-03-23 Treatment of multiple sclerosis with anti-measles cow colostrum Ebina, T. Sato, A. Umezu, K. Aso, H. Ishida, N. Seki, H. Tsukamoto, T. Takase, S. Hoshi, S. Ohta, M. Med Microbiol Immunol Article Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobulin resistant to proteases. This colostrum was orally administered to patients with MS to investigate its effect on the course of the disease. Measles-positive antibody colostrum was orally administered every morning to 15 patients with MS at a daily dosage of 100 ml for 30 days. Similarly, measles-negative antibody (< 8) control colostrum was orally administered to 5 patients. As a clinical assessment, disability scores developed by the International Federation of Multiple Sclerosis Societies were used. As a result, of 7 high NT titre (512–5120) anti-measles colostrum recipients 5 patients improved and 2 remained unchanged. Among 8 low NT titre (8–32) anti-measles colostrum recipients 5 patients improved and 3 remained unchanged. However, of 5 negative NT titre (< 8) colostrum recipients 2 patients remained unchanged and 3 worsened. No side-effects were observed in colostrum recipients. These findings suggest the efficacy of orally administered anti-measles colostrum in improving the condition of MS patients (P < 0.05). Springer-Verlag 1984 /pmc/articles/PMC7087162/ /pubmed/6493135 http://dx.doi.org/10.1007/BF02124822 Text en © Springer-Verlag 1984 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ebina, T.
Sato, A.
Umezu, K.
Aso, H.
Ishida, N.
Seki, H.
Tsukamoto, T.
Takase, S.
Hoshi, S.
Ohta, M.
Treatment of multiple sclerosis with anti-measles cow colostrum
title Treatment of multiple sclerosis with anti-measles cow colostrum
title_full Treatment of multiple sclerosis with anti-measles cow colostrum
title_fullStr Treatment of multiple sclerosis with anti-measles cow colostrum
title_full_unstemmed Treatment of multiple sclerosis with anti-measles cow colostrum
title_short Treatment of multiple sclerosis with anti-measles cow colostrum
title_sort treatment of multiple sclerosis with anti-measles cow colostrum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087162/
https://www.ncbi.nlm.nih.gov/pubmed/6493135
http://dx.doi.org/10.1007/BF02124822
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