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Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6
Freshly isolated monocytes rapidly undergo physiological changes in vitro, resulting in programmed cell death (apoptosis). Activation of monocytes, which promotes differentiation into macrophages, is known to inhibit apoptotic processes. In the present study, we report that human herpesvirus-6 (HHV-...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087170/ https://www.ncbi.nlm.nih.gov/pubmed/16474928 http://dx.doi.org/10.1007/s00705-005-0715-6 |
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author | Janelle, M.-E. Flamand, L. |
author_facet | Janelle, M.-E. Flamand, L. |
author_sort | Janelle, M.-E. |
collection | PubMed |
description | Freshly isolated monocytes rapidly undergo physiological changes in vitro, resulting in programmed cell death (apoptosis). Activation of monocytes, which promotes differentiation into macrophages, is known to inhibit apoptotic processes. In the present study, we report that human herpesvirus-6 (HHV-6) prevents monocytes from undergoing spontaneous apoptosis during the first 72 hours of culture. Furthermore, significant alterations in cell-surface phenotype were observed after 72 hours of infection with HHV-6. HHV-6-infected monocyte cultures have considerably reduced levels of CD14, CD64 (FcγRI) and HLA-DR antigen on their surface, while CD32 (FcγRII) expression is unaffected. On the basis of these results, we hypothesize that HHV-6 promotes monocytes survival and causes phenotypic modifications that could favor immune evasion and ensure its persistence within the infected host. |
format | Online Article Text |
id | pubmed-7087170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70871702020-03-23 Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 Janelle, M.-E. Flamand, L. Arch Virol Article Freshly isolated monocytes rapidly undergo physiological changes in vitro, resulting in programmed cell death (apoptosis). Activation of monocytes, which promotes differentiation into macrophages, is known to inhibit apoptotic processes. In the present study, we report that human herpesvirus-6 (HHV-6) prevents monocytes from undergoing spontaneous apoptosis during the first 72 hours of culture. Furthermore, significant alterations in cell-surface phenotype were observed after 72 hours of infection with HHV-6. HHV-6-infected monocyte cultures have considerably reduced levels of CD14, CD64 (FcγRI) and HLA-DR antigen on their surface, while CD32 (FcγRII) expression is unaffected. On the basis of these results, we hypothesize that HHV-6 promotes monocytes survival and causes phenotypic modifications that could favor immune evasion and ensure its persistence within the infected host. Springer-Verlag 2006-02-13 2006 /pmc/articles/PMC7087170/ /pubmed/16474928 http://dx.doi.org/10.1007/s00705-005-0715-6 Text en © Springer-Verlag 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Janelle, M.-E. Flamand, L. Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
title | Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
title_full | Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
title_fullStr | Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
title_full_unstemmed | Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
title_short | Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
title_sort | phenotypic alterations and survival of monocytes following infection by human herpesvirus-6 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087170/ https://www.ncbi.nlm.nih.gov/pubmed/16474928 http://dx.doi.org/10.1007/s00705-005-0715-6 |
work_keys_str_mv | AT janelleme phenotypicalterationsandsurvivalofmonocytesfollowinginfectionbyhumanherpesvirus6 AT flamandl phenotypicalterationsandsurvivalofmonocytesfollowinginfectionbyhumanherpesvirus6 |