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Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine
The claim that it is possible to rationally design a structure-based HIV-1 vaccine is based on misconceptions regarding the nature of protein epitopes and of immunological specificity. Attempts to use reverse vaccinology to generate an HIV-1 vaccine on the basis of the structure of viral epitopes bo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Vienna
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087187/ https://www.ncbi.nlm.nih.gov/pubmed/22012269 http://dx.doi.org/10.1007/s00705-011-1145-2 |