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Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates

To investigate whether the feline CD 4 (fCD 4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD 4 stably on Crandell feline kidney cells andFelis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD 4 glycopro...

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Autores principales: Norimine, J., Miyazawa, T., Kawaguchi, Y., Tomonaga, K., Shin, Y. -S., Toyosaki, T., Kohmoto, M., Niikura, M., Tohya, Y., Mikami, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087261/
https://www.ncbi.nlm.nih.gov/pubmed/8389115
http://dx.doi.org/10.1007/BF01319005
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author Norimine, J.
Miyazawa, T.
Kawaguchi, Y.
Tomonaga, K.
Shin, Y. -S.
Toyosaki, T.
Kohmoto, M.
Niikura, M.
Tohya, Y.
Mikami, T.
author_facet Norimine, J.
Miyazawa, T.
Kawaguchi, Y.
Tomonaga, K.
Shin, Y. -S.
Toyosaki, T.
Kohmoto, M.
Niikura, M.
Tohya, Y.
Mikami, T.
author_sort Norimine, J.
collection PubMed
description To investigate whether the feline CD 4 (fCD 4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD 4 stably on Crandell feline kidney cells andFelis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD 4 glycoprotein, and then infected them with TM 1 and TM 2 strains of FIV, which are unable to infect these cells productively. In spite of fCD 4 being expressed on these cells, no virus production was observed. This result indicates that fCD 4 expression alone cannot induce a productive infection of the FIV TM 1 and TM 2 strains.
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spelling pubmed-70872612020-03-23 Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates Norimine, J. Miyazawa, T. Kawaguchi, Y. Tomonaga, K. Shin, Y. -S. Toyosaki, T. Kohmoto, M. Niikura, M. Tohya, Y. Mikami, T. Arch Virol Brief Report To investigate whether the feline CD 4 (fCD 4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD 4 stably on Crandell feline kidney cells andFelis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD 4 glycoprotein, and then infected them with TM 1 and TM 2 strains of FIV, which are unable to infect these cells productively. In spite of fCD 4 being expressed on these cells, no virus production was observed. This result indicates that fCD 4 expression alone cannot induce a productive infection of the FIV TM 1 and TM 2 strains. Springer-Verlag 1993 /pmc/articles/PMC7087261/ /pubmed/8389115 http://dx.doi.org/10.1007/BF01319005 Text en © Springer-Verlag 1993 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Norimine, J.
Miyazawa, T.
Kawaguchi, Y.
Tomonaga, K.
Shin, Y. -S.
Toyosaki, T.
Kohmoto, M.
Niikura, M.
Tohya, Y.
Mikami, T.
Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
title Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
title_full Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
title_fullStr Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
title_full_unstemmed Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
title_short Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
title_sort feline cd 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087261/
https://www.ncbi.nlm.nih.gov/pubmed/8389115
http://dx.doi.org/10.1007/BF01319005
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