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Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog
A 5-year-old female Yorkshire terrier dog died a few days following hernia and ovariohysterectomy surgeries. Necropsy performed on the dog revealed that the surgeries were not the cause of death; however, degenerative viral hepatitis, showing intranuclear inclusion bodies in hepatic cells, was obser...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087280/ https://www.ncbi.nlm.nih.gov/pubmed/27251050 http://dx.doi.org/10.1007/s00705-016-2895-7 |
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author | Choi, Jeong-Won Jung, Ji-Youl Lee, Jae-Il Lee, Kyoung-Ki Oem, Jae-Ku |
author_facet | Choi, Jeong-Won Jung, Ji-Youl Lee, Jae-Il Lee, Kyoung-Ki Oem, Jae-Ku |
author_sort | Choi, Jeong-Won |
collection | PubMed |
description | A 5-year-old female Yorkshire terrier dog died a few days following hernia and ovariohysterectomy surgeries. Necropsy performed on the dog revealed that the surgeries were not the cause of death; however, degenerative viral hepatitis, showing intranuclear inclusion bodies in hepatic cells, was observed in histopathologic examination. Several diagnostic methods were used to screen for the cause of disease, and minute virus of canines (MVC) was detected in all parenchymal organs, including the liver. Other pathogens that may cause degenerative viral hepatitis were not found. Infection with MVC was confirmed by in situ hybridization, which revealed the presence of MVC nucleic acid in the liver tissue of the dog. Through sequencing and phylogenetic analysis of the nearly complete genome sequence, the strain was found to be distinct from other previously reported MVC strains. These results indicate that this novel MVC strain might be related to degenerative viral hepatitis in dogs. |
format | Online Article Text |
id | pubmed-7087280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-70872802020-03-23 Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog Choi, Jeong-Won Jung, Ji-Youl Lee, Jae-Il Lee, Kyoung-Ki Oem, Jae-Ku Arch Virol Brief Report A 5-year-old female Yorkshire terrier dog died a few days following hernia and ovariohysterectomy surgeries. Necropsy performed on the dog revealed that the surgeries were not the cause of death; however, degenerative viral hepatitis, showing intranuclear inclusion bodies in hepatic cells, was observed in histopathologic examination. Several diagnostic methods were used to screen for the cause of disease, and minute virus of canines (MVC) was detected in all parenchymal organs, including the liver. Other pathogens that may cause degenerative viral hepatitis were not found. Infection with MVC was confirmed by in situ hybridization, which revealed the presence of MVC nucleic acid in the liver tissue of the dog. Through sequencing and phylogenetic analysis of the nearly complete genome sequence, the strain was found to be distinct from other previously reported MVC strains. These results indicate that this novel MVC strain might be related to degenerative viral hepatitis in dogs. Springer Vienna 2016-06-01 2016 /pmc/articles/PMC7087280/ /pubmed/27251050 http://dx.doi.org/10.1007/s00705-016-2895-7 Text en © Springer-Verlag Wien 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Brief Report Choi, Jeong-Won Jung, Ji-Youl Lee, Jae-Il Lee, Kyoung-Ki Oem, Jae-Ku Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
title | Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
title_full | Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
title_fullStr | Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
title_full_unstemmed | Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
title_short | Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
title_sort | molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087280/ https://www.ncbi.nlm.nih.gov/pubmed/27251050 http://dx.doi.org/10.1007/s00705-016-2895-7 |
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