Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

BACKGROUND: CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem. RESULTS: Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers and pr...

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Detalles Bibliográficos
Autores principales: Jia, Zhilian, Li, Jingwei, Ge, Xiao, Wu, Yonghu, Guo, Ya, Wu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087399/
https://www.ncbi.nlm.nih.gov/pubmed/32293525
http://dx.doi.org/10.1186/s13059-020-01984-7

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