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Complement, viruses, and virus-infected cells
The attachment of specific antibody to viral glycoproteins and other structures on the surface of a virus or virus-infected cell has a number of potential consequences to the virus or virus-infected cell. Antibody is multivalent and thus able to redistribute or patch surface viral proteins or virus-...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
1983
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087538/ https://www.ncbi.nlm.nih.gov/pubmed/6364429 http://dx.doi.org/10.1007/BF02116278 |
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author | Cooper, Neil R. Nemerow, Glen R. |
author_facet | Cooper, Neil R. Nemerow, Glen R. |
author_sort | Cooper, Neil R. |
collection | PubMed |
description | The attachment of specific antibody to viral glycoproteins and other structures on the surface of a virus or virus-infected cell has a number of potential consequences to the virus or virus-infected cell. Antibody is multivalent and thus able to redistribute or patch surface viral proteins or virus-encoded structures within the lipid bilayer of the viral envelope or the cell membrane. In certain instances, antibody may agglutinate viruses or virus-infected cells. The physical presence of antibody molecules on the virus surface may interfere with the ability of the virus to infect potentially susceptible cells. Antibody on the surface of virus-infected cells may prevent the maturation and release of virus particles; antibody also can alter certain normal cell functions. The Fc portions of antibody molecules bound to virus-infected cells facilitate interactions with effector cells bearing Fc receptors. In the case of lymphocytes and perhaps phagocytic cells, this interaction may lead to antibody-dependent cellular cytotoxicity (ADCC) [51, 58]. The exposed Fc regions may also facilitate attempts at ingestion by monocytes, macrophages, and polymorphonuclear leukocytes. |
format | Online Article Text |
id | pubmed-7087538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1983 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70875382020-03-23 Complement, viruses, and virus-infected cells Cooper, Neil R. Nemerow, Glen R. Springer Semin Immunopathol Article The attachment of specific antibody to viral glycoproteins and other structures on the surface of a virus or virus-infected cell has a number of potential consequences to the virus or virus-infected cell. Antibody is multivalent and thus able to redistribute or patch surface viral proteins or virus-encoded structures within the lipid bilayer of the viral envelope or the cell membrane. In certain instances, antibody may agglutinate viruses or virus-infected cells. The physical presence of antibody molecules on the virus surface may interfere with the ability of the virus to infect potentially susceptible cells. Antibody on the surface of virus-infected cells may prevent the maturation and release of virus particles; antibody also can alter certain normal cell functions. The Fc portions of antibody molecules bound to virus-infected cells facilitate interactions with effector cells bearing Fc receptors. In the case of lymphocytes and perhaps phagocytic cells, this interaction may lead to antibody-dependent cellular cytotoxicity (ADCC) [51, 58]. The exposed Fc regions may also facilitate attempts at ingestion by monocytes, macrophages, and polymorphonuclear leukocytes. Springer-Verlag 1983 /pmc/articles/PMC7087538/ /pubmed/6364429 http://dx.doi.org/10.1007/BF02116278 Text en © Springer-Verlag 1983 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Cooper, Neil R. Nemerow, Glen R. Complement, viruses, and virus-infected cells |
title | Complement, viruses, and virus-infected cells |
title_full | Complement, viruses, and virus-infected cells |
title_fullStr | Complement, viruses, and virus-infected cells |
title_full_unstemmed | Complement, viruses, and virus-infected cells |
title_short | Complement, viruses, and virus-infected cells |
title_sort | complement, viruses, and virus-infected cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087538/ https://www.ncbi.nlm.nih.gov/pubmed/6364429 http://dx.doi.org/10.1007/BF02116278 |
work_keys_str_mv | AT cooperneilr complementvirusesandvirusinfectedcells AT nemerowglenr complementvirusesandvirusinfectedcells |