Cargando…

Effect of New Antiviral Agent Camphecin on Behavior of Mice

We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produ...

Descripción completa

Detalles Bibliográficos
Autores principales: Babina, A. V., Lavrinenko, V. A., Yarovaya, O. I., Salakhutdinov, N. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087596/
https://www.ncbi.nlm.nih.gov/pubmed/28091927
http://dx.doi.org/10.1007/s10517-017-3612-6
_version_ 1783509362949488640
author Babina, A. V.
Lavrinenko, V. A.
Yarovaya, O. I.
Salakhutdinov, N. F.
author_facet Babina, A. V.
Lavrinenko, V. A.
Yarovaya, O. I.
Salakhutdinov, N. F.
author_sort Babina, A. V.
collection PubMed
description We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior.
format Online
Article
Text
id pubmed-7087596
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-70875962020-03-23 Effect of New Antiviral Agent Camphecin on Behavior of Mice Babina, A. V. Lavrinenko, V. A. Yarovaya, O. I. Salakhutdinov, N. F. Bull Exp Biol Med Pharmacology and Toxicology We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior. Springer US 2017-01-16 2017 /pmc/articles/PMC7087596/ /pubmed/28091927 http://dx.doi.org/10.1007/s10517-017-3612-6 Text en © Springer Science+Business Media New York 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Pharmacology and Toxicology
Babina, A. V.
Lavrinenko, V. A.
Yarovaya, O. I.
Salakhutdinov, N. F.
Effect of New Antiviral Agent Camphecin on Behavior of Mice
title Effect of New Antiviral Agent Camphecin on Behavior of Mice
title_full Effect of New Antiviral Agent Camphecin on Behavior of Mice
title_fullStr Effect of New Antiviral Agent Camphecin on Behavior of Mice
title_full_unstemmed Effect of New Antiviral Agent Camphecin on Behavior of Mice
title_short Effect of New Antiviral Agent Camphecin on Behavior of Mice
title_sort effect of new antiviral agent camphecin on behavior of mice
topic Pharmacology and Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087596/
https://www.ncbi.nlm.nih.gov/pubmed/28091927
http://dx.doi.org/10.1007/s10517-017-3612-6
work_keys_str_mv AT babinaav effectofnewantiviralagentcamphecinonbehaviorofmice
AT lavrinenkova effectofnewantiviralagentcamphecinonbehaviorofmice
AT yarovayaoi effectofnewantiviralagentcamphecinonbehaviorofmice
AT salakhutdinovnf effectofnewantiviralagentcamphecinonbehaviorofmice