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Effect of New Antiviral Agent Camphecin on Behavior of Mice
We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087596/ https://www.ncbi.nlm.nih.gov/pubmed/28091927 http://dx.doi.org/10.1007/s10517-017-3612-6 |
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author | Babina, A. V. Lavrinenko, V. A. Yarovaya, O. I. Salakhutdinov, N. F. |
author_facet | Babina, A. V. Lavrinenko, V. A. Yarovaya, O. I. Salakhutdinov, N. F. |
author_sort | Babina, A. V. |
collection | PubMed |
description | We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior. |
format | Online Article Text |
id | pubmed-7087596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-70875962020-03-23 Effect of New Antiviral Agent Camphecin on Behavior of Mice Babina, A. V. Lavrinenko, V. A. Yarovaya, O. I. Salakhutdinov, N. F. Bull Exp Biol Med Pharmacology and Toxicology We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior. Springer US 2017-01-16 2017 /pmc/articles/PMC7087596/ /pubmed/28091927 http://dx.doi.org/10.1007/s10517-017-3612-6 Text en © Springer Science+Business Media New York 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Pharmacology and Toxicology Babina, A. V. Lavrinenko, V. A. Yarovaya, O. I. Salakhutdinov, N. F. Effect of New Antiviral Agent Camphecin on Behavior of Mice |
title | Effect of New Antiviral Agent Camphecin on Behavior of Mice |
title_full | Effect of New Antiviral Agent Camphecin on Behavior of Mice |
title_fullStr | Effect of New Antiviral Agent Camphecin on Behavior of Mice |
title_full_unstemmed | Effect of New Antiviral Agent Camphecin on Behavior of Mice |
title_short | Effect of New Antiviral Agent Camphecin on Behavior of Mice |
title_sort | effect of new antiviral agent camphecin on behavior of mice |
topic | Pharmacology and Toxicology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087596/ https://www.ncbi.nlm.nih.gov/pubmed/28091927 http://dx.doi.org/10.1007/s10517-017-3612-6 |
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