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Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions

We studied the efficacy of umbilical cord blood cells in the therapy of treatment-resistant depressive states in women. Concentrated umbilical cord blood cells were administered in a dose of 250 millions cells (4 injections at 1-week intervals). The control group received placebo. In both groups, re...

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Detalles Bibliográficos
Autores principales: Smulevich, A. B., Dubnitskaya, E. B., Voronova, E. I., Morozova, Ya. V., Radaev, S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087609/
https://www.ncbi.nlm.nih.gov/pubmed/26899842
http://dx.doi.org/10.1007/s10517-016-3222-8
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author Smulevich, A. B.
Dubnitskaya, E. B.
Voronova, E. I.
Morozova, Ya. V.
Radaev, S. M.
author_facet Smulevich, A. B.
Dubnitskaya, E. B.
Voronova, E. I.
Morozova, Ya. V.
Radaev, S. M.
author_sort Smulevich, A. B.
collection PubMed
description We studied the efficacy of umbilical cord blood cells in the therapy of treatment-resistant depressive states in women. Concentrated umbilical cord blood cells were administered in a dose of 250 millions cells (4 injections at 1-week intervals). The control group received placebo. In both groups, reduction of depressive disorders and the decrease in hypothymia severity were observed. Infusions of cell concentrate contributed to delayed correction of treatment resistance and reduced the severity of depression to moderate. In the main group, significant, persistent, and long-term positive dynamics was observed in the cognitive sphere. The therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients.
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spelling pubmed-70876092020-03-23 Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions Smulevich, A. B. Dubnitskaya, E. B. Voronova, E. I. Morozova, Ya. V. Radaev, S. M. Bull Exp Biol Med Article We studied the efficacy of umbilical cord blood cells in the therapy of treatment-resistant depressive states in women. Concentrated umbilical cord blood cells were administered in a dose of 250 millions cells (4 injections at 1-week intervals). The control group received placebo. In both groups, reduction of depressive disorders and the decrease in hypothymia severity were observed. Infusions of cell concentrate contributed to delayed correction of treatment resistance and reduced the severity of depression to moderate. In the main group, significant, persistent, and long-term positive dynamics was observed in the cognitive sphere. The therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients. Springer US 2016-02-22 2016 /pmc/articles/PMC7087609/ /pubmed/26899842 http://dx.doi.org/10.1007/s10517-016-3222-8 Text en © Springer Science+Business Media New York 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Smulevich, A. B.
Dubnitskaya, E. B.
Voronova, E. I.
Morozova, Ya. V.
Radaev, S. M.
Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions
title Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions
title_full Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions
title_fullStr Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions
title_full_unstemmed Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions
title_short Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions
title_sort efficiency of umbilical cord blood cells in patients with treatment-resistant depressions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087609/
https://www.ncbi.nlm.nih.gov/pubmed/26899842
http://dx.doi.org/10.1007/s10517-016-3222-8
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