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Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy

Recently Simmons et al. reported a new mechanism for SARS virus entry into target cells, where MDL28170 was identified as an efficient inhibitor of CTSL-meditated substrate cleavage with IC(50) of 2.5 nmol/l. Based on the molecule fingerprint searching method, 11 natural molecules were found in the...

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Detalles Bibliográficos
Autores principales:	Wang, S.-Q., Du, Q.-S., Zhao, K., Li, A.-X., Wei, D.-Q., Chou, K.-C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087620/ https://www.ncbi.nlm.nih.gov/pubmed/16998715 http://dx.doi.org/10.1007/s00726-006-0403-1

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