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Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections

Upper respiratory tract infections (URTIs) are characterised by a neutrophilic mucosal infiltration. The purpose of this study was to investigate the time course of release of the cytokines/chemokines interleukins (IL) IL-1β, IL-1ra, tumour necrosis factor-α (TNF-α), IL-6, IL-8, interferon-γ (IFN-γ)...

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Autores principales: Bachert, C., van Kempen, M. J. P. K, Höpken, K., Holtappels, G., Wagenmann, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087684/
https://www.ncbi.nlm.nih.gov/pubmed/11724263
http://dx.doi.org/10.1007/s004050100363
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author Bachert, C.
van Kempen, M. J. P. K
Höpken, K.
Holtappels, G.
Wagenmann, M.
author_facet Bachert, C.
van Kempen, M. J. P. K
Höpken, K.
Holtappels, G.
Wagenmann, M.
author_sort Bachert, C.
collection PubMed
description Upper respiratory tract infections (URTIs) are characterised by a neutrophilic mucosal infiltration. The purpose of this study was to investigate the time course of release of the cytokines/chemokines interleukins (IL) IL-1β, IL-1ra, tumour necrosis factor-α (TNF-α), IL-6, IL-8, interferon-γ (IFN-γ) and monocyte chemotactic protein (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), myeloperoxidase (MPO) and bradykinin in nasal secretions of patients with a naturally acquired URTI. A total of 117 healthy adult volunteers were recruited for baseline nasal lavages, 39 of whom developed URTI symptoms within 6 months and returned to our centre within 48 h. Lavages were performed daily during the symptomatic period and 3 weeks thereafter, with symptoms no longer present. Compared to baseline, significantly elevated concentrations of total protein, bradykinin, IL-1β, TNF-α, IL-6, IL-8, MCP-1, IFN-γ, MPO and sICAM-1 were detected in nasal lavage fluids of symptomatic patients, whereas IL-1ra remained unaltered. All studied variables reached baseline 3 weeks after the URTI. Naturally acquired URTI represent a limited, neutrophilic inflammatory reaction, orchestrated by the release of pro-inflammatory cytokines and chemokines.
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spelling pubmed-70876842020-03-23 Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections Bachert, C. van Kempen, M. J. P. K Höpken, K. Holtappels, G. Wagenmann, M. Eur Arch Otorhinolaryngol Miscellaneous Upper respiratory tract infections (URTIs) are characterised by a neutrophilic mucosal infiltration. The purpose of this study was to investigate the time course of release of the cytokines/chemokines interleukins (IL) IL-1β, IL-1ra, tumour necrosis factor-α (TNF-α), IL-6, IL-8, interferon-γ (IFN-γ) and monocyte chemotactic protein (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), myeloperoxidase (MPO) and bradykinin in nasal secretions of patients with a naturally acquired URTI. A total of 117 healthy adult volunteers were recruited for baseline nasal lavages, 39 of whom developed URTI symptoms within 6 months and returned to our centre within 48 h. Lavages were performed daily during the symptomatic period and 3 weeks thereafter, with symptoms no longer present. Compared to baseline, significantly elevated concentrations of total protein, bradykinin, IL-1β, TNF-α, IL-6, IL-8, MCP-1, IFN-γ, MPO and sICAM-1 were detected in nasal lavage fluids of symptomatic patients, whereas IL-1ra remained unaltered. All studied variables reached baseline 3 weeks after the URTI. Naturally acquired URTI represent a limited, neutrophilic inflammatory reaction, orchestrated by the release of pro-inflammatory cytokines and chemokines. Springer-Verlag 2001 /pmc/articles/PMC7087684/ /pubmed/11724263 http://dx.doi.org/10.1007/s004050100363 Text en © Springer-Verlag Berlin Heidelberg 2001 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Miscellaneous
Bachert, C.
van Kempen, M. J. P. K
Höpken, K.
Holtappels, G.
Wagenmann, M.
Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
title Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
title_full Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
title_fullStr Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
title_full_unstemmed Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
title_short Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
title_sort elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections
topic Miscellaneous
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087684/
https://www.ncbi.nlm.nih.gov/pubmed/11724263
http://dx.doi.org/10.1007/s004050100363
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