Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives

ABSTRACT: New series of Schiff’s bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone deri...

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Detalles Bibliográficos
Autores principales: Abbas, Samir Y., Farag, Awatef A., Ammar, Yousry A., Atrees, Abeer A., Mohamed, Aly F., El-Henawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087807/
https://www.ncbi.nlm.nih.gov/pubmed/32214479
http://dx.doi.org/10.1007/s00706-013-1034-3
Descripción
Sumario:ABSTRACT: New series of Schiff’s bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity. GRAPHICAL ABSTRACT: [Image: see text]

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