Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives

ABSTRACT: New series of Schiff’s bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone deri...

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Detalles Bibliográficos
Autores principales: Abbas, Samir Y., Farag, Awatef A., Ammar, Yousry A., Atrees, Abeer A., Mohamed, Aly F., El-Henawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087807/
https://www.ncbi.nlm.nih.gov/pubmed/32214479
http://dx.doi.org/10.1007/s00706-013-1034-3
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author Abbas, Samir Y.
Farag, Awatef A.
Ammar, Yousry A.
Atrees, Abeer A.
Mohamed, Aly F.
El-Henawy, Ahmed A.
author_facet Abbas, Samir Y.
Farag, Awatef A.
Ammar, Yousry A.
Atrees, Abeer A.
Mohamed, Aly F.
El-Henawy, Ahmed A.
author_sort Abbas, Samir Y.
collection PubMed
description ABSTRACT: New series of Schiff’s bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-70878072020-03-23 Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives Abbas, Samir Y. Farag, Awatef A. Ammar, Yousry A. Atrees, Abeer A. Mohamed, Aly F. El-Henawy, Ahmed A. Monatsh Chem Original Paper ABSTRACT: New series of Schiff’s bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity. GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2013-07-12 2013 /pmc/articles/PMC7087807/ /pubmed/32214479 http://dx.doi.org/10.1007/s00706-013-1034-3 Text en © Springer-Verlag Wien 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Abbas, Samir Y.
Farag, Awatef A.
Ammar, Yousry A.
Atrees, Abeer A.
Mohamed, Aly F.
El-Henawy, Ahmed A.
Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
title Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
title_full Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
title_fullStr Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
title_full_unstemmed Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
title_short Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
title_sort synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087807/
https://www.ncbi.nlm.nih.gov/pubmed/32214479
http://dx.doi.org/10.1007/s00706-013-1034-3
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