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Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types

Human rhinovirus (HRV) is a highly prevalent pathogen and a major cause of acute respiratory tract infection (ARTI). HRV express less seasonality than other viral ARTIs, which typically appear as seasonal epidemics lasting for 1–2 months. The aim of this study was to investigate the seasonal pattern...

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Autores principales: Sansone, M., Andersson, M., Brittain-Long, R., Andersson, L.-M., Olofsson, S., Westin, J., Lindh, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087832/
https://www.ncbi.nlm.nih.gov/pubmed/23435753
http://dx.doi.org/10.1007/s10096-013-1832-x
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author Sansone, M.
Andersson, M.
Brittain-Long, R.
Andersson, L.-M.
Olofsson, S.
Westin, J.
Lindh, M.
author_facet Sansone, M.
Andersson, M.
Brittain-Long, R.
Andersson, L.-M.
Olofsson, S.
Westin, J.
Lindh, M.
author_sort Sansone, M.
collection PubMed
description Human rhinovirus (HRV) is a highly prevalent pathogen and a major cause of acute respiratory tract infection (ARTI). HRV express less seasonality than other viral ARTIs, which typically appear as seasonal epidemics lasting for 1–2 months. The aim of this study was to investigate the seasonal patterns of HRV types over four consecutive years in one geographic region. HRV identified in respiratory samples from 114 patients over a four-year period were analysed by VP4/VP2 sequencing. HRV-A was found in 64, HRV-B in 11 and HRV-C in 37 cases. Overall, 33 different HRV-A types, nine B types and 21 C types were found. As many as 21 of the HRV types appeared during several seasons, with a maximum time-span of four years. Some types appeared during successive seasons and, in some cases, phylogenetic analysis indicated extended periods of circulation locally. Most of the strains were closely related to HRV identified in other parts of the world during the same time period. HRV strains that circulate locally represent many types and seem to reflect that HRV infections are highly globalised. The existence of simultaneous or successive epidemics with different HRV types in combination with the ability of each type to remain in the local population over extended periods of time may contribute to explaining the high rate of HRV infections.
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spelling pubmed-70878322020-03-23 Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types Sansone, M. Andersson, M. Brittain-Long, R. Andersson, L.-M. Olofsson, S. Westin, J. Lindh, M. Eur J Clin Microbiol Infect Dis Article Human rhinovirus (HRV) is a highly prevalent pathogen and a major cause of acute respiratory tract infection (ARTI). HRV express less seasonality than other viral ARTIs, which typically appear as seasonal epidemics lasting for 1–2 months. The aim of this study was to investigate the seasonal patterns of HRV types over four consecutive years in one geographic region. HRV identified in respiratory samples from 114 patients over a four-year period were analysed by VP4/VP2 sequencing. HRV-A was found in 64, HRV-B in 11 and HRV-C in 37 cases. Overall, 33 different HRV-A types, nine B types and 21 C types were found. As many as 21 of the HRV types appeared during several seasons, with a maximum time-span of four years. Some types appeared during successive seasons and, in some cases, phylogenetic analysis indicated extended periods of circulation locally. Most of the strains were closely related to HRV identified in other parts of the world during the same time period. HRV strains that circulate locally represent many types and seem to reflect that HRV infections are highly globalised. The existence of simultaneous or successive epidemics with different HRV types in combination with the ability of each type to remain in the local population over extended periods of time may contribute to explaining the high rate of HRV infections. Springer-Verlag 2013-02-23 2013 /pmc/articles/PMC7087832/ /pubmed/23435753 http://dx.doi.org/10.1007/s10096-013-1832-x Text en © Springer-Verlag Berlin Heidelberg 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Sansone, M.
Andersson, M.
Brittain-Long, R.
Andersson, L.-M.
Olofsson, S.
Westin, J.
Lindh, M.
Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types
title Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types
title_full Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types
title_fullStr Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types
title_full_unstemmed Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types
title_short Rhinovirus infections in western Sweden: a four-year molecular epidemiology study comparing local and globally appearing types
title_sort rhinovirus infections in western sweden: a four-year molecular epidemiology study comparing local and globally appearing types
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087832/
https://www.ncbi.nlm.nih.gov/pubmed/23435753
http://dx.doi.org/10.1007/s10096-013-1832-x
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