Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives

Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1′-aryl-3′-methyl-5′-androstano[17,16-d]pyrazolines prepared by us earlier.

Detalles Bibliográficos
Autores principales: Nadaraia, N. Sh., Barbakadze, N. N., Kakhabrishvili, M. L., Sylla, B., Pichette, A., Makhmudov, U. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087839/
https://www.ncbi.nlm.nih.gov/pubmed/32214425
http://dx.doi.org/10.1007/s10600-018-2330-2
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author Nadaraia, N. Sh.
Barbakadze, N. N.
Kakhabrishvili, M. L.
Sylla, B.
Pichette, A.
Makhmudov, U. S.
author_facet Nadaraia, N. Sh.
Barbakadze, N. N.
Kakhabrishvili, M. L.
Sylla, B.
Pichette, A.
Makhmudov, U. S.
author_sort Nadaraia, N. Sh.
collection PubMed
description Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1′-aryl-3′-methyl-5′-androstano[17,16-d]pyrazolines prepared by us earlier.
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spelling pubmed-70878392020-03-23 Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives Nadaraia, N. Sh. Barbakadze, N. N. Kakhabrishvili, M. L. Sylla, B. Pichette, A. Makhmudov, U. S. Chem Nat Compd Article Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1′-aryl-3′-methyl-5′-androstano[17,16-d]pyrazolines prepared by us earlier. Springer US 2018-04-14 2018 /pmc/articles/PMC7087839/ /pubmed/32214425 http://dx.doi.org/10.1007/s10600-018-2330-2 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Nadaraia, N. Sh.
Barbakadze, N. N.
Kakhabrishvili, M. L.
Sylla, B.
Pichette, A.
Makhmudov, U. S.
Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
title Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
title_full Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
title_fullStr Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
title_full_unstemmed Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
title_short Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives
title_sort synthesis and biological activity of several modified 5α-androstanolone derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087839/
https://www.ncbi.nlm.nih.gov/pubmed/32214425
http://dx.doi.org/10.1007/s10600-018-2330-2
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