Materno-fetal transmission of human coronaviruses: a prospective pilot study

This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples dur...

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Autores principales: Gagneur, A., Dirson, E., Audebert, S., Vallet, S., Legrand-Quillien, M. C., Laurent, Y., Collet, M., Sizun, J., Oger, E., Payan, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Concise Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087967/
https://www.ncbi.nlm.nih.gov/pubmed/18373106
http://dx.doi.org/10.1007/s10096-008-0505-7
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author Gagneur, A.
Dirson, E.
Audebert, S.
Vallet, S.
Legrand-Quillien, M. C.
Laurent, Y.
Collet, M.
Sizun, J.
Oger, E.
Payan, C.
author_facet Gagneur, A.
Dirson, E.
Audebert, S.
Vallet, S.
Legrand-Quillien, M. C.
Laurent, Y.
Collet, M.
Sizun, J.
Oger, E.
Payan, C.
author_sort Gagneur, A.
collection PubMed
description This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.
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spelling pubmed-70879672020-03-23 Materno-fetal transmission of human coronaviruses: a prospective pilot study Gagneur, A. Dirson, E. Audebert, S. Vallet, S. Legrand-Quillien, M. C. Laurent, Y. Collet, M. Sizun, J. Oger, E. Payan, C. Eur J Clin Microbiol Infect Dis Concise Article This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale. Springer-Verlag 2008-03-29 2008 /pmc/articles/PMC7087967/ /pubmed/18373106 http://dx.doi.org/10.1007/s10096-008-0505-7 Text en © Springer-Verlag 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Concise Article
Gagneur, A.
Dirson, E.
Audebert, S.
Vallet, S.
Legrand-Quillien, M. C.
Laurent, Y.
Collet, M.
Sizun, J.
Oger, E.
Payan, C.
Materno-fetal transmission of human coronaviruses: a prospective pilot study
title Materno-fetal transmission of human coronaviruses: a prospective pilot study
title_full Materno-fetal transmission of human coronaviruses: a prospective pilot study
title_fullStr Materno-fetal transmission of human coronaviruses: a prospective pilot study
title_full_unstemmed Materno-fetal transmission of human coronaviruses: a prospective pilot study
title_short Materno-fetal transmission of human coronaviruses: a prospective pilot study
title_sort materno-fetal transmission of human coronaviruses: a prospective pilot study
topic Concise Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087967/
https://www.ncbi.nlm.nih.gov/pubmed/18373106
http://dx.doi.org/10.1007/s10096-008-0505-7
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