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The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs
We aimed to describe the potential benefit of new rapid molecular respiratory tests (MRT) in decreasing inappropriate antibiotic use among the inpatients presenting with influenza-like illness (ILI). We included patients from inpatient and outpatient departments who had ILI and performed MRT between...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087990/ https://www.ncbi.nlm.nih.gov/pubmed/29332209 http://dx.doi.org/10.1007/s10096-017-3174-6 |
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author | Keske, Şiran Ergönül, Önder Tutucu, Faik Karaaslan, Doruk Palaoğlu, Erhan Can, Füsun |
author_facet | Keske, Şiran Ergönül, Önder Tutucu, Faik Karaaslan, Doruk Palaoğlu, Erhan Can, Füsun |
author_sort | Keske, Şiran |
collection | PubMed |
description | We aimed to describe the potential benefit of new rapid molecular respiratory tests (MRT) in decreasing inappropriate antibiotic use among the inpatients presenting with influenza-like illness (ILI). We included patients from inpatient and outpatient departments who had ILI and performed MRT between 1 January 2015 and 31 December 2016 in a 265-bed private hospital in Istanbul. At the end of 2015, we implemented antimicrobial stewardship including systematic use of MRT. Then, we compared our observations between the year 2015 and the year 2016. We designed the study according to the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) tool. A U.S. Food and Drug Administration (FDA)-cleared multiplexed polymerase chain reaction (PCR) system (BioFire FilmArray, Idaho Technology, Salt Lake City, UT) which detects 17 viruses and three bacteria was used for diagnosis. In total, 1317 patients were included; 630 (48%) were inpatients and 569 (43%) were older than 16 years of age. At least one virus was detected in 747 (57%) patients. Rhinovirus/enterovirus, influenza virus, and adenovirus were the most commonly detected. Among hospitalized patients, in children, a significant decrease in antibiotic use (44.5% in 2015 and 28.8% in 2016, p = 0.009) was observed, but in adults, the decrease was not statistically significant (72% in 2015 and 63% in 2016, p = 0.36). The duration of antibiotic use after the detection of virus was significantly decreased in both children and adults (p < 0.001 and p = 0.007, respectively). By using MRT, inappropriate antibiotic use and, also, duration of inappropriate antibiotic use after the detection of virus was significantly decreased. It is time to increase the awareness about the viral etiology in respiratory tract infections (RTIs) and implement MRT in clinical practice. |
format | Online Article Text |
id | pubmed-7087990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-70879902020-03-23 The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs Keske, Şiran Ergönül, Önder Tutucu, Faik Karaaslan, Doruk Palaoğlu, Erhan Can, Füsun Eur J Clin Microbiol Infect Dis Original Article We aimed to describe the potential benefit of new rapid molecular respiratory tests (MRT) in decreasing inappropriate antibiotic use among the inpatients presenting with influenza-like illness (ILI). We included patients from inpatient and outpatient departments who had ILI and performed MRT between 1 January 2015 and 31 December 2016 in a 265-bed private hospital in Istanbul. At the end of 2015, we implemented antimicrobial stewardship including systematic use of MRT. Then, we compared our observations between the year 2015 and the year 2016. We designed the study according to the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) tool. A U.S. Food and Drug Administration (FDA)-cleared multiplexed polymerase chain reaction (PCR) system (BioFire FilmArray, Idaho Technology, Salt Lake City, UT) which detects 17 viruses and three bacteria was used for diagnosis. In total, 1317 patients were included; 630 (48%) were inpatients and 569 (43%) were older than 16 years of age. At least one virus was detected in 747 (57%) patients. Rhinovirus/enterovirus, influenza virus, and adenovirus were the most commonly detected. Among hospitalized patients, in children, a significant decrease in antibiotic use (44.5% in 2015 and 28.8% in 2016, p = 0.009) was observed, but in adults, the decrease was not statistically significant (72% in 2015 and 63% in 2016, p = 0.36). The duration of antibiotic use after the detection of virus was significantly decreased in both children and adults (p < 0.001 and p = 0.007, respectively). By using MRT, inappropriate antibiotic use and, also, duration of inappropriate antibiotic use after the detection of virus was significantly decreased. It is time to increase the awareness about the viral etiology in respiratory tract infections (RTIs) and implement MRT in clinical practice. Springer Berlin Heidelberg 2018-01-13 2018 /pmc/articles/PMC7087990/ /pubmed/29332209 http://dx.doi.org/10.1007/s10096-017-3174-6 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Keske, Şiran Ergönül, Önder Tutucu, Faik Karaaslan, Doruk Palaoğlu, Erhan Can, Füsun The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
title | The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
title_full | The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
title_fullStr | The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
title_full_unstemmed | The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
title_short | The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
title_sort | rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087990/ https://www.ncbi.nlm.nih.gov/pubmed/29332209 http://dx.doi.org/10.1007/s10096-017-3174-6 |
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