Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2

We investigated the effect of exogenous mouse α-+β-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4...

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Autores principales: Kato, Yasuhiro, Noda, Yatsugi, Unoura, Masashi, Tanaka, Nobuyoshi, Kobayashi, Kenichi, Hattori, Nobu, Hatano, Kiichi, Kobayashi, Shigeyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers-Plenum Publishers 1986
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088026/
https://www.ncbi.nlm.nih.gov/pubmed/3002736
http://dx.doi.org/10.1007/BF01300705
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author Kato, Yasuhiro
Noda, Yatsugi
Unoura, Masashi
Tanaka, Nobuyoshi
Kobayashi, Kenichi
Hattori, Nobu
Hatano, Kiichi
Kobayashi, Shigeyasu
author_facet Kato, Yasuhiro
Noda, Yatsugi
Unoura, Masashi
Tanaka, Nobuyoshi
Kobayashi, Kenichi
Hattori, Nobu
Hatano, Kiichi
Kobayashi, Shigeyasu
author_sort Kato, Yasuhiro
collection PubMed
description We investigated the effect of exogenous mouse α-+β-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4-week-old male ICR mice by intraperitoneal inoculation of MHV-2. Mouse interferon (10(3) IU/mouse/day) was intraperitoneally injected every day. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and development of liver cell necrosis, and prolonged the survival. It was also found that the earlier mouse interferon was administered, the greater was the prolongation of survival.
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spelling pubmed-70880262020-03-23 Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2 Kato, Yasuhiro Noda, Yatsugi Unoura, Masashi Tanaka, Nobuyoshi Kobayashi, Kenichi Hattori, Nobu Hatano, Kiichi Kobayashi, Shigeyasu Dig Dis Sci Original Articles We investigated the effect of exogenous mouse α-+β-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4-week-old male ICR mice by intraperitoneal inoculation of MHV-2. Mouse interferon (10(3) IU/mouse/day) was intraperitoneally injected every day. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and development of liver cell necrosis, and prolonged the survival. It was also found that the earlier mouse interferon was administered, the greater was the prolongation of survival. Kluwer Academic Publishers-Plenum Publishers 1986 /pmc/articles/PMC7088026/ /pubmed/3002736 http://dx.doi.org/10.1007/BF01300705 Text en © Plenum Publishing Corporation 1986 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Articles
Kato, Yasuhiro
Noda, Yatsugi
Unoura, Masashi
Tanaka, Nobuyoshi
Kobayashi, Kenichi
Hattori, Nobu
Hatano, Kiichi
Kobayashi, Shigeyasu
Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
title Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
title_full Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
title_fullStr Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
title_full_unstemmed Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
title_short Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
title_sort effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088026/
https://www.ncbi.nlm.nih.gov/pubmed/3002736
http://dx.doi.org/10.1007/BF01300705
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