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Glycosylated human interleukin-1α, neoglyco IL-1α, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution

In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1α. NeuAc-coupled IL-1α (NeuAc-IL-1α) exhibited reduced activities in vitro and...

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Detalles Bibliográficos
Autores principales:	Sasayama, Satoshi, Moriya, Kayoko, Chiba, Taku, Matsumura, Takayuki, Hayashi, Hidetoshi, Hayashi, Akiko, Onozaki, Kikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Kluwer Academic Publishers-Plenum Publishers 2000
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088040/ https://www.ncbi.nlm.nih.gov/pubmed/11294501 http://dx.doi.org/10.1023/A:1007181929405

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