A dynamic model for the p53 stress response networks under ion radiation

P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways. To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular level, a dynamic model for the p53 stress r...

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Detalles Bibliográficos
Autores principales: Qi, J.-P., Shao, S.-H., Li, D.-D., Zhou, G.-P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088058/
https://www.ncbi.nlm.nih.gov/pubmed/17072789
http://dx.doi.org/10.1007/s00726-006-0454-3
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author Qi, J.-P.
Shao, S.-H.
Li, D.-D.
Zhou, G.-P.
author_facet Qi, J.-P.
Shao, S.-H.
Li, D.-D.
Zhou, G.-P.
author_sort Qi, J.-P.
collection PubMed
description P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways. To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular level, a dynamic model for the p53 stress response networks is proposed. The model can be successfully used to simulate the dynamic processes of generating the double-strand breaks (DSBs) and their repairing, ataxia telangiectasia mutated (ATM) activation, as well as the oscillations occurring in the p53-MDM2 feedback loop.
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spelling pubmed-70880582020-03-23 A dynamic model for the p53 stress response networks under ion radiation Qi, J.-P. Shao, S.-H. Li, D.-D. Zhou, G.-P. Amino Acids Article P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways. To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular level, a dynamic model for the p53 stress response networks is proposed. The model can be successfully used to simulate the dynamic processes of generating the double-strand breaks (DSBs) and their repairing, ataxia telangiectasia mutated (ATM) activation, as well as the oscillations occurring in the p53-MDM2 feedback loop. Springer-Verlag 2006-10-31 2007 /pmc/articles/PMC7088058/ /pubmed/17072789 http://dx.doi.org/10.1007/s00726-006-0454-3 Text en © Springer-Verlag 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Qi, J.-P.
Shao, S.-H.
Li, D.-D.
Zhou, G.-P.
A dynamic model for the p53 stress response networks under ion radiation
title A dynamic model for the p53 stress response networks under ion radiation
title_full A dynamic model for the p53 stress response networks under ion radiation
title_fullStr A dynamic model for the p53 stress response networks under ion radiation
title_full_unstemmed A dynamic model for the p53 stress response networks under ion radiation
title_short A dynamic model for the p53 stress response networks under ion radiation
title_sort dynamic model for the p53 stress response networks under ion radiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088058/
https://www.ncbi.nlm.nih.gov/pubmed/17072789
http://dx.doi.org/10.1007/s00726-006-0454-3
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