Inhibitory effect of flavonoids against NS2B-NS3 protease of ZIKA virus and their structure activity relationship

OBJECTIVES: To determine the inhibitory activities of flavonoids against NS2B-NS3 protease of ZIKA virus (ZIKV NS2B-NS3(pro)) expressed in Escherichia coli BL21 (DE3) and their structure activity relationship. RESULTS: ZIKV NS2B-NS3(pro) was expressed in E. coli BL21(DE3) as a 35 kDa protein. It had...

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Detalles Bibliográficos
Autores principales: Lim, Hee-jung, Nguyen, Thi Thanh Hanh, Kim, Nahyun M., Park, Jun-Seong, Jang, Tae-Su, Kim, Doman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088272/
https://www.ncbi.nlm.nih.gov/pubmed/27885509
http://dx.doi.org/10.1007/s10529-016-2261-6

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