Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters

New conjugates of 18β- and 18α-glycyrrhizic acids (GAs) each containing two di- or α-methyl esters of L-aspartic acid in the carbohydrate part of the glycosides were synthesized by the activated ester method using the N-hydroxysuccinimide (HOSu) and N,N'-dicyclohexylcarbodiimide. It was found t...

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Autores principales: Baltina, L. A., Chistoedova, E. S., Kondratenko, R. M., Plyasunova, O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088273/
https://www.ncbi.nlm.nih.gov/pubmed/32214422
http://dx.doi.org/10.1007/s10600-012-0217-1
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author Baltina, L. A.
Chistoedova, E. S.
Baltina, L. A.
Kondratenko, R. M.
Plyasunova, O. A.
author_facet Baltina, L. A.
Chistoedova, E. S.
Baltina, L. A.
Kondratenko, R. M.
Plyasunova, O. A.
author_sort Baltina, L. A.
collection PubMed
description New conjugates of 18β- and 18α-glycyrrhizic acids (GAs) each containing two di- or α-methyl esters of L-aspartic acid in the carbohydrate part of the glycosides were synthesized by the activated ester method using the N-hydroxysuccinimide (HOSu) and N,N'-dicyclohexylcarbodiimide. It was found that the conjugate of 18β-GA with Asp(OMe)(OMe) (4) at a concentration of 250 μg/mL inhibited effectively RT of HIV-1 and the accumulation of virus antigen p24 in MT-4 cell culture (95–97 %) and protected cells from the cytopathogenic action of the virus.
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spelling pubmed-70882732020-03-23 Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters Baltina, L. A. Chistoedova, E. S. Baltina, L. A. Kondratenko, R. M. Plyasunova, O. A. Chem Nat Compd Article New conjugates of 18β- and 18α-glycyrrhizic acids (GAs) each containing two di- or α-methyl esters of L-aspartic acid in the carbohydrate part of the glycosides were synthesized by the activated ester method using the N-hydroxysuccinimide (HOSu) and N,N'-dicyclohexylcarbodiimide. It was found that the conjugate of 18β-GA with Asp(OMe)(OMe) (4) at a concentration of 250 μg/mL inhibited effectively RT of HIV-1 and the accumulation of virus antigen p24 in MT-4 cell culture (95–97 %) and protected cells from the cytopathogenic action of the virus. Springer US 2012-05-16 2012 /pmc/articles/PMC7088273/ /pubmed/32214422 http://dx.doi.org/10.1007/s10600-012-0217-1 Text en © Springer Science+Business Media, Inc. 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Baltina, L. A.
Chistoedova, E. S.
Baltina, L. A.
Kondratenko, R. M.
Plyasunova, O. A.
Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
title Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
title_full Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
title_fullStr Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
title_full_unstemmed Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
title_short Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
title_sort synthesis and anti-hiv-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088273/
https://www.ncbi.nlm.nih.gov/pubmed/32214422
http://dx.doi.org/10.1007/s10600-012-0217-1
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