4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids

Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxici...

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Detalles Bibliográficos
Autores principales: Ukrainets, I. V., Bereznyakova, N. L., Turaibei, I. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088292/
https://www.ncbi.nlm.nih.gov/pubmed/32214416
http://dx.doi.org/10.1007/s10593-008-0012-x
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author Ukrainets, I. V.
Bereznyakova, N. L.
Turaibei, I. A.
author_facet Ukrainets, I. V.
Bereznyakova, N. L.
Turaibei, I. A.
author_sort Ukrainets, I. V.
collection PubMed
description Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
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spelling pubmed-70882922020-03-23 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids Ukrainets, I. V. Bereznyakova, N. L. Turaibei, I. A. Chem Heterocycl Compd (N Y) Article Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus. Springer US 2008-05-31 2008 /pmc/articles/PMC7088292/ /pubmed/32214416 http://dx.doi.org/10.1007/s10593-008-0012-x Text en © Springer Science+Business Media, Inc. 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ukrainets, I. V.
Bereznyakova, N. L.
Turaibei, I. A.
4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
title 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
title_full 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
title_fullStr 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
title_full_unstemmed 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
title_short 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
title_sort 4-hydroxy-2-quinolones 139. synthesis, structure, and antiviral activity of n-r-amides of 2-hydroxy-4-oxo-4h-pyrido[1,2-a]pyrimidine-3-carboxylic acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088292/
https://www.ncbi.nlm.nih.gov/pubmed/32214416
http://dx.doi.org/10.1007/s10593-008-0012-x
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