Enhancing immune responses against SARS-CoV nucleocapsid DNA vaccine by co-inoculating interleukin-2 expressing vector in mice

The immunogenicity of SARS-CoV nucleocapsid DNA vaccine and the immunoregulatory activity of interleukin-2 (IL-2) were investigated. DNA vaccine plasmids, pcDNA-N and pcDNA-IL2, were constructed and inoculated into BALB/c mice with or without pcDNA-IL2 by intramuscular injection. Cellular and humora...

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Detalles Bibliográficos
Autores principales: Hu, Hui, Tao, Ling, Wang, Yabin, Chen, Liying, Yang, Jihong, Wang, Hanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088336/
https://www.ncbi.nlm.nih.gov/pubmed/19579009
http://dx.doi.org/10.1007/s10529-009-0061-y

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