Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs

[Image: see text] The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that...

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Detalles Bibliográficos
Autores principales: Voskoboynik, Oleksii Yu., Kolomoets, Oleksandra S., Berest, Galyna G., Nosulenko, Inna S., Martynenko, Yuliya V., Kovalenko, Sergiy I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088342/
https://www.ncbi.nlm.nih.gov/pubmed/32214419
http://dx.doi.org/10.1007/s10593-017-2048-2
Descripción
Sumario:[Image: see text] The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer.

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