Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs

[Image: see text] The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that...

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Autores principales: Voskoboynik, Oleksii Yu., Kolomoets, Oleksandra S., Berest, Galyna G., Nosulenko, Inna S., Martynenko, Yuliya V., Kovalenko, Sergiy I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088342/
https://www.ncbi.nlm.nih.gov/pubmed/32214419
http://dx.doi.org/10.1007/s10593-017-2048-2
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author Voskoboynik, Oleksii Yu.
Kolomoets, Oleksandra S.
Berest, Galyna G.
Nosulenko, Inna S.
Martynenko, Yuliya V.
Kovalenko, Sergiy I.
author_facet Voskoboynik, Oleksii Yu.
Kolomoets, Oleksandra S.
Berest, Galyna G.
Nosulenko, Inna S.
Martynenko, Yuliya V.
Kovalenko, Sergiy I.
author_sort Voskoboynik, Oleksii Yu.
collection PubMed
description [Image: see text] The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer.
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spelling pubmed-70883422020-03-23 Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs Voskoboynik, Oleksii Yu. Kolomoets, Oleksandra S. Berest, Galyna G. Nosulenko, Inna S. Martynenko, Yuliya V. Kovalenko, Sergiy I. Chem Heterocycl Compd (N Y) Article [Image: see text] The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer. Springer US 2017-04-27 2017 /pmc/articles/PMC7088342/ /pubmed/32214419 http://dx.doi.org/10.1007/s10593-017-2048-2 Text en © Springer Science+Business Media New York 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Voskoboynik, Oleksii Yu.
Kolomoets, Oleksandra S.
Berest, Galyna G.
Nosulenko, Inna S.
Martynenko, Yuliya V.
Kovalenko, Sergiy I.
Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
title Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
title_full Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
title_fullStr Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
title_full_unstemmed Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
title_short Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
title_sort preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088342/
https://www.ncbi.nlm.nih.gov/pubmed/32214419
http://dx.doi.org/10.1007/s10593-017-2048-2
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