Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate

Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.

Detalles Bibliográficos
Autores principales: Balzarini, J., Ruchko, E. A., Zakharova, E. K., Kameneva, I. Yu., Nawrozkij, M. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088350/
https://www.ncbi.nlm.nih.gov/pubmed/32214417
http://dx.doi.org/10.1007/s10593-014-1499-y
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author Balzarini, J.
Ruchko, E. A.
Zakharova, E. K.
Kameneva, I. Yu.
Nawrozkij, M. B.
author_facet Balzarini, J.
Ruchko, E. A.
Zakharova, E. K.
Kameneva, I. Yu.
Nawrozkij, M. B.
author_sort Balzarini, J.
collection PubMed
description Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.
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spelling pubmed-70883502020-03-23 Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate Balzarini, J. Ruchko, E. A. Zakharova, E. K. Kameneva, I. Yu. Nawrozkij, M. B. Chem Heterocycl Compd (N Y) Article Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study. Springer US 2014-06-08 2014 /pmc/articles/PMC7088350/ /pubmed/32214417 http://dx.doi.org/10.1007/s10593-014-1499-y Text en © Springer Science+Business Media New York 2014 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Balzarini, J.
Ruchko, E. A.
Zakharova, E. K.
Kameneva, I. Yu.
Nawrozkij, M. B.
Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate
title Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate
title_full Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate
title_fullStr Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate
title_full_unstemmed Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate
title_short Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate
title_sort structural analogs of umifenovir. 1. synthesis and biological activity of ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1h-indole-3-carboxylate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088350/
https://www.ncbi.nlm.nih.gov/pubmed/32214417
http://dx.doi.org/10.1007/s10593-014-1499-y
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