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Sialic acids as receptor determinants for coronaviruses

Among coronaviruses, several members are able to interact with sialic acids. For bovine coronavirus (BCoV) and related viruses, binding to cell surface components containing N-acetyl-9- O-acetylneuraminic acid is essential for initiation of an infection. These viruses resemble influenza C viruses be...

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Autores principales: Schwegmann-Weßels, Christel, Herrler, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088368/
https://www.ncbi.nlm.nih.gov/pubmed/16575522
http://dx.doi.org/10.1007/s10719-006-5437-9
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author Schwegmann-Weßels, Christel
Herrler, Georg
author_facet Schwegmann-Weßels, Christel
Herrler, Georg
author_sort Schwegmann-Weßels, Christel
collection PubMed
description Among coronaviruses, several members are able to interact with sialic acids. For bovine coronavirus (BCoV) and related viruses, binding to cell surface components containing N-acetyl-9- O-acetylneuraminic acid is essential for initiation of an infection. These viruses resemble influenza C viruses because they share not only the receptor determinant, but also the presence of an acetylesterase that releases the 9- O-acetyl group from sialic acid and thus abolishes the ability of the respective sialoglycoconjugate to function as a receptor for BCoV. As in the case of influenza viruses, the receptor-destroying enzyme of BCoV is believed to facilitate the spread of virus infection by removing receptor determinants from the surface of infected cells and by preventing the formation of virus aggregates. Another coronavirus, porcine transmissible gastroenteritis virus (TGEV) preferentially recognizes N-glycolylneuraminic acid. TGEV does not contain a receptor-destroying enzyme and does not depend on the sialic acid binding activity for infection of cultured cells. However, binding to sialic acids is required for the enteropathogenicity of TGEV. Interaction with sialoglycoconjugates may help the virus to pass through the sialic acid-rich mucus layer that covers the viral target cells in the epithelium of the small intestine. We discuss that the BCoV group of viruses may have evolved from a TGEV-like ancestor by acquiring an acetylesterase gene through heterologous recombination.
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spelling pubmed-70883682020-03-23 Sialic acids as receptor determinants for coronaviruses Schwegmann-Weßels, Christel Herrler, Georg Glycoconj J Mini Review Among coronaviruses, several members are able to interact with sialic acids. For bovine coronavirus (BCoV) and related viruses, binding to cell surface components containing N-acetyl-9- O-acetylneuraminic acid is essential for initiation of an infection. These viruses resemble influenza C viruses because they share not only the receptor determinant, but also the presence of an acetylesterase that releases the 9- O-acetyl group from sialic acid and thus abolishes the ability of the respective sialoglycoconjugate to function as a receptor for BCoV. As in the case of influenza viruses, the receptor-destroying enzyme of BCoV is believed to facilitate the spread of virus infection by removing receptor determinants from the surface of infected cells and by preventing the formation of virus aggregates. Another coronavirus, porcine transmissible gastroenteritis virus (TGEV) preferentially recognizes N-glycolylneuraminic acid. TGEV does not contain a receptor-destroying enzyme and does not depend on the sialic acid binding activity for infection of cultured cells. However, binding to sialic acids is required for the enteropathogenicity of TGEV. Interaction with sialoglycoconjugates may help the virus to pass through the sialic acid-rich mucus layer that covers the viral target cells in the epithelium of the small intestine. We discuss that the BCoV group of viruses may have evolved from a TGEV-like ancestor by acquiring an acetylesterase gene through heterologous recombination. Kluwer Academic Publishers 2006 /pmc/articles/PMC7088368/ /pubmed/16575522 http://dx.doi.org/10.1007/s10719-006-5437-9 Text en © Springer Science + Business Media, LLC 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Mini Review
Schwegmann-Weßels, Christel
Herrler, Georg
Sialic acids as receptor determinants for coronaviruses
title Sialic acids as receptor determinants for coronaviruses
title_full Sialic acids as receptor determinants for coronaviruses
title_fullStr Sialic acids as receptor determinants for coronaviruses
title_full_unstemmed Sialic acids as receptor determinants for coronaviruses
title_short Sialic acids as receptor determinants for coronaviruses
title_sort sialic acids as receptor determinants for coronaviruses
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088368/
https://www.ncbi.nlm.nih.gov/pubmed/16575522
http://dx.doi.org/10.1007/s10719-006-5437-9
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