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Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak

Pneumoviruses have been identified as causative agents in several respiratory disease outbreaks in habituated wild great apes. Based on phylogenetic evidence, transmission from humans is likely. However, the pathogens have never been detected in the local human population prior to or at the same tim...

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Autores principales: Grützmacher, Kim S., Köndgen, Sophie, Keil, Verena, Todd, Angelique, Feistner, Anna, Herbinger, Ilka, Petrzelkova, Klara, Fuh, Terrence, Leendertz, Siv Aina, Calvignac-Spencer, Sébastien, Leendertz, Fabian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088376/
https://www.ncbi.nlm.nih.gov/pubmed/27436109
http://dx.doi.org/10.1007/s10393-016-1144-6
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author Grützmacher, Kim S.
Köndgen, Sophie
Keil, Verena
Todd, Angelique
Feistner, Anna
Herbinger, Ilka
Petrzelkova, Klara
Fuh, Terrence
Leendertz, Siv Aina
Calvignac-Spencer, Sébastien
Leendertz, Fabian H.
author_facet Grützmacher, Kim S.
Köndgen, Sophie
Keil, Verena
Todd, Angelique
Feistner, Anna
Herbinger, Ilka
Petrzelkova, Klara
Fuh, Terrence
Leendertz, Siv Aina
Calvignac-Spencer, Sébastien
Leendertz, Fabian H.
author_sort Grützmacher, Kim S.
collection PubMed
description Pneumoviruses have been identified as causative agents in several respiratory disease outbreaks in habituated wild great apes. Based on phylogenetic evidence, transmission from humans is likely. However, the pathogens have never been detected in the local human population prior to or at the same time as an outbreak. Here, we report the first simultaneous detection of a human respiratory syncytial virus (HRSV) infection in western lowland gorillas (Gorilla gorilla gorilla) and in the local human population at a field program in the Central African Republic. A total of 15 gorilla and 15 human fecal samples and 80 human throat swabs were tested for HRSV, human metapneumovirus, and other respiratory viruses. We were able to obtain identical sequences for HRSV A from four gorillas and four humans. In contrast, we did not detect HRSV or any other classic human respiratory virus in gorilla fecal samples in two other outbreaks in the same field program. Enterovirus sequences were detected but the implication of these viruses in the etiology of these outbreaks remains speculative. Our findings of HRSV in wild but human-habituated gorillas underline, once again, the risk of interspecies transmission from humans to endangered great apes.
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spelling pubmed-70883762020-03-23 Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak Grützmacher, Kim S. Köndgen, Sophie Keil, Verena Todd, Angelique Feistner, Anna Herbinger, Ilka Petrzelkova, Klara Fuh, Terrence Leendertz, Siv Aina Calvignac-Spencer, Sébastien Leendertz, Fabian H. Ecohealth Original Contribution Pneumoviruses have been identified as causative agents in several respiratory disease outbreaks in habituated wild great apes. Based on phylogenetic evidence, transmission from humans is likely. However, the pathogens have never been detected in the local human population prior to or at the same time as an outbreak. Here, we report the first simultaneous detection of a human respiratory syncytial virus (HRSV) infection in western lowland gorillas (Gorilla gorilla gorilla) and in the local human population at a field program in the Central African Republic. A total of 15 gorilla and 15 human fecal samples and 80 human throat swabs were tested for HRSV, human metapneumovirus, and other respiratory viruses. We were able to obtain identical sequences for HRSV A from four gorillas and four humans. In contrast, we did not detect HRSV or any other classic human respiratory virus in gorilla fecal samples in two other outbreaks in the same field program. Enterovirus sequences were detected but the implication of these viruses in the etiology of these outbreaks remains speculative. Our findings of HRSV in wild but human-habituated gorillas underline, once again, the risk of interspecies transmission from humans to endangered great apes. Springer US 2016-07-19 2016 /pmc/articles/PMC7088376/ /pubmed/27436109 http://dx.doi.org/10.1007/s10393-016-1144-6 Text en © International Association for Ecology and Health 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Contribution
Grützmacher, Kim S.
Köndgen, Sophie
Keil, Verena
Todd, Angelique
Feistner, Anna
Herbinger, Ilka
Petrzelkova, Klara
Fuh, Terrence
Leendertz, Siv Aina
Calvignac-Spencer, Sébastien
Leendertz, Fabian H.
Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
title Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
title_full Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
title_fullStr Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
title_full_unstemmed Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
title_short Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak
title_sort codetection of respiratory syncytial virus in habituated wild western lowland gorillas and humans during a respiratory disease outbreak
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088376/
https://www.ncbi.nlm.nih.gov/pubmed/27436109
http://dx.doi.org/10.1007/s10393-016-1144-6
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