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Scorpion Venom–Toxins that Aid in Drug Development: A Review

Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal disorders. They can modulate the ion channels (K(+), Na(+), Cl(−), Ca(2+)) of our body and this concept has been hypothesized in formulating pharmaceuticals. The triumphant achievem...

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Detalles Bibliográficos
Autores principales: Ghosh, Arijit, Roy, Rini, Nandi, Monoswini, Mukhopadhyay, Ashis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088386/
https://www.ncbi.nlm.nih.gov/pubmed/32214927
http://dx.doi.org/10.1007/s10989-018-9721-x
Descripción
Sumario:Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal disorders. They can modulate the ion channels (K(+), Na(+), Cl(−), Ca(2+)) of our body and this concept has been hypothesized in formulating pharmaceuticals. The triumphant achievement of these venom components as formulated anticancer agent in Phase I and Phase II clinical trials allure researchers to excavate beneficial venom components prohibiting DNA replication in malignant tumor cells. This review brings forth the achievements of Science and Technology in classifying the venom components as therapeutics and further application in drug product development.